Limb Lengthening Forum

Limb Lengthening Surgery => Limb Lengthening Discussions => Topic started by: brondo on September 01, 2020, 11:37:31 AM

Title: What is the future of limb lengthening? What do you hope to see happen?
Post by: brondo on September 01, 2020, 11:37:31 AM
I am new to the world of limb lengthening, but it seems like the technology seen some really great improvements with things like the Stryde nail. What kind of advancements do you think will be in store in the future? What do you think needs to happen in the future or near future that we can improve upon either technology wise, process wise, culture wise, etc? Of course we would all like to take a pill and get taller, but realistically what do you think can happen?
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: a on September 01, 2020, 12:02:13 PM
The bone consolidation will be faster than ever, they are gonna use stem cells.

But, I don't think there is going to be huge improvements about muscles.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: F_99 on September 01, 2020, 12:04:46 PM
Quote
What do you hope to see happen?

Not necessarily surgery related, but check out these (recent ones):

https://www.tapatalk.com/groups/lsjl/the-most-important-topic-in-growth-plate-reopening-t1029-s10.html

http://www.limblengtheningforum.com/index.php?topic=65449.0

http://med.stanford.edu/news/all-news/2020/08/Researchers-find-method-to-regrow-cartilage-in-the-joints.html

https://www.fightaging.org/archives/2020/08/adenosine-injected-into-arthritic-joints-produces-cartilage-regrowth/

https://www.reddit.com/r/looksmaxxing/comments/hmj34y/what_future_heightmaxxing_regimen_may_look/


Now as for the surgery, I would imagine a better/stronger/thinner(?) nail, drugs that alleviate pain more efficiently, stem cells for faster healing and the like, and possibly some kind of growth hormone drug supplementation.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: a on September 01, 2020, 12:51:54 PM
The nirvana would be: Re-Opening Growth Plates With Pills with minimal side effects.

But its gonna probably take a decade or more. Maybe 50 years. Maybe never.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: ChefCurtis30 on September 01, 2020, 03:57:42 PM
Ik that there is a new nail currently having clinical trials right now. Its called the Synoste Nitinail and supposedly, it has full 100% weight bearing capacity from day one post op and the lengthening process can be controlled through ur phone. Only for femurs tho T T. But maybe stem cell treatment after lengthening can speed up the consolidation phase.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: brondo on September 01, 2020, 04:23:04 PM
This must be it right: https://clinicaltrials.gov/ct2/show/NCT03752814. Hopefully it will be successful.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Kenda on September 01, 2020, 05:39:35 PM
Not necessarily surgery related, but check out these (recent ones):

https://www.tapatalk.com/groups/lsjl/the-most-important-topic-in-growth-plate-reopening-t1029-s10.html

http://www.limblengtheningforum.com/index.php?topic=65449.0

http://med.stanford.edu/news/all-news/2020/08/Researchers-find-method-to-regrow-cartilage-in-the-joints.html

https://www.fightaging.org/archives/2020/08/adenosine-injected-into-arthritic-joints-produces-cartilage-regrowth/

https://www.reddit.com/r/looksmaxxing/comments/hmj34y/what_future_heightmaxxing_regimen_may_look/


Now as for the surgery, I would imagine a better/stronger/thinner(?) nail, drugs that alleviate pain more efficiently, stem cells for faster healing and the like, and possibly some kind of growth hormone drug supplementation.


Do you think that taking HGH at 21 years old could help in any way ? or Growth Hormone should be taken after the surgery only?
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: F_99 on September 01, 2020, 06:30:59 PM

Do you think that taking HGH at 21 years old could help in any way ? or Growth Hormone should be taken after the surgery only?

I'm actually 21 and no, unless your growth plates are open, which is extremely rare, HGH won't do anything, GH or Ipamorelin / CJC 1295 during the bone lengthening phase for faster healing might be the way to go. 

However, if it's possible to reopen a growth plate with C16H10N2O2 or something similar, you'd need a GH / (GH) mimicking drug after that to continue (I think).
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: ChefCurtis30 on September 01, 2020, 06:37:42 PM
This must be it right: https://clinicaltrials.gov/ct2/show/NCT03752814. Hopefully it will be successful.
Yes this is the trial. The trial ends in 2021. This will be a big game changer for LL. I heard the app for Nitinail will tell you when you are lengthening too much per day. Too bad its only for femur tho.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: BetzLandLiberator on September 01, 2020, 08:00:32 PM
It's an Stryde with a cell phone app. That's not an improvement. Not really an evolution. Just slight more convenient.
And now ALL the big corporations in the world will know if you did LL, because they will link the app to your data.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: BelowTheMean on September 02, 2020, 12:04:12 AM
It's an Stryde with a cell phone app. That's not an improvement. Not really an evolution. Just slight more convenient.
And now ALL the big corporations in the world will know if you did LL, because they will link the app to your data.

It’s also a brand new nail whereas Stryde has at least a few hundred if not thousand implants already.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: F_99 on September 02, 2020, 03:03:04 PM
It's an Stryde with a cell phone app. That's not an improvement. Not really an evolution. Just slight more convenient.
And now ALL the big corporations in the world will know if you did LL, because they will link the app to your data.

+1
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Body Builder on September 02, 2020, 10:41:50 PM
Stryde is the best we would have for at least the next 20 years.
Doing LL and walking almost immediately is revolutionary, nothing else can be done for the next many years.
And to be honest, that's more than enough. If someone is determined to do a so invasive and risky procedure to just become taller, then Stryde is more than enough for him.
I would be very grateful if I have that opportunity 10 years ago that I did my LL with the awful monorails that didn't even let me stand for 3-4 months, nor even thinking of walking.

The only drawback for stryde and LL generally is the huge price.
No other cosmetic procedure is even close to being so much expensive.
You should be rich to do LL with Stryde. Many women complain because they don't have 3-4.000 euro to do a boobjob, which is an easy surgery with great results amd we must pay 50.000+ euro to break our bones, harming our athletic abilities by some percentage (from a few to too much) and facing many risks and pain for months.
Yes, life is unfair. But still, LL makes it more fair but with a high price in money and risks.

Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Tengo on September 03, 2020, 10:25:21 AM
More scientific papers and communication between LL doctors will help improve current techniques or maybe create new ones.

I wonder if some kind of hot bath therapy would let soft tissue stretch and consolidate easier?
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: brondo on September 03, 2020, 11:38:49 AM
More scientific papers and communication between LL doctors will help improve current techniques or maybe create new ones.

I wonder if some kind of hot bath therapy would let soft tissue stretch and consolidate easier?

Yeah, this is what I hope will happen more. I hope that the community will start to take shape and from there you will start to see the advancements snowball.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: F_99 on September 03, 2020, 07:39:06 PM
Stryde is the best we would have for at least the next 20 years.
Doing LL and walking almost immediately is revolutionary, nothing else can be done for the next many years.

No one can predict the future.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Kenda on September 04, 2020, 11:18:29 AM
I'm actually 21 and no, unless your growth plates are open, which is extremely rare, HGH won't do anything, GH or Ipamorelin / CJC 1295 during the bone lengthening phase for faster healing might be the way to go. 

However, if it's possible to reopen a growth plate with C16H10N2O2 or something similar, you'd need a GH / (GH) mimicking drug after that to continue (I think).


Bone growth plate reopen?!!! thats insane and 100x better than surgery

Do you know any DR who specializes in this?
Did you ask dr paley about it??

Is  C16H10N2O2   a chemical or hormone that makes these plates reopen?
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Kenda on September 04, 2020, 11:20:24 AM
ofcourse even if there is a way to open growth plates these drs would rather tell patients surgery is the only way so they can make more money
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: F_99 on September 04, 2020, 12:29:04 PM

Bone growth plate reopen?!!! thats insane and 100x better than surgery


Is  C16H10N2O2   a chemical or hormone that makes these plates reopen?

C16H10N2O2 is this
https://en.wikipedia.org/wiki/Indirubin

Those 5 above are possible future solutions. This is the most interesting one:
https://www.reddit.com/r/looksmaxxing/comments/hmj34y/what_future_heightmaxxing_regimen_may_look/

Quote
Do you know any DR who specializes in this?
Did you ask dr paley about it??

You answered yourself with this

Quote
ofcourse even if there is a way to open growth plates these drs would rather tell patients surgery is the only way so they can make more money

I think we should be (as a community) more interested in surgery alternatives. This surgery is no joke. Chronic pain, premature arthritis, complications, non unions, grandpa walking for the rest of your life, hardware fails, reduced athletic ability and similar BS. Expensive as hell. Like I could buy a used Ferrari 360 or a house instead of going to Paley or Guichet for example.
http://www.limblengtheningforum.com/index.php?topic=64405.0
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: a on September 04, 2020, 12:37:13 PM
As I've mentioned before, the nirvana of this topic would be having a "growth opener" pills as an alternative, when you drink the pill on a daily basis, it pushes the growth plates and they re-open. I know it sounded stupid like a fairytale. But imagine that, wouldn't it be the TOP maximum of the stature lengthening?

edit: God knows if that would be possible even in 50 years. Idfk. Not rly into biology.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Body Builder on September 04, 2020, 12:44:45 PM
More scientific papers and communication between LL doctors will help improve current techniques or maybe create new ones.

I wonder if some kind of hot bath therapy would let soft tissue stretch and consolidate easier?
Stryde is a huge step forward.
Having something not visible inside your bone that let you lengthen while you make your everyday routine is something all LLers ever dreamed of.

Most of you should be very happy that something like that exists and plan your LL if you really want it.
Nothing will change for the next many years, at least drastically , so talking about gene therapy and all these is completely meaningless.
You'll be very old if all these are geting real sometime so it won't matter.

Stryde is the future of LL and with a good doctor LL has become easier and safer than ever. The only thing that must change are the insane prices, nothing else.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: F_99 on September 04, 2020, 12:55:23 PM
Nothing will change for the next many years, at least drastically , so talking about gene therapy and all these is completely meaningless.
You'll be very old if all these are geting real sometime so it won't matter.

Again, no one can predict the future. But the question in the post was also "What do you hope to see happen?"

Quote
Stryde is the future of LL and with a good doctor LL has become easier and safer than ever. The only thing that must change are the insane prices, nothing else.

If a non invasive alternative will come out and be available on the market, you're free to go to support those millionaire NW($) orthopedic surgeons.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Ghostfish on September 05, 2020, 05:33:53 AM
Stryde is the best we would have for at least the next 20 years.
Doing LL and walking almost immediately is revolutionary, nothing else can be done for the next many years.
And to be honest, that's more than enough. If someone is determined to do a so invasive and risky procedure to just become taller, then Stryde is more than enough for him.
I would be very grateful if I have that opportunity 10 years ago that I did my LL with the awful monorails that didn't even let me stand for 3-4 months, nor even thinking of walking.

The only drawback for stryde and LL generally is the huge price.
No other cosmetic procedure is even close to being so much expensive.
You should be rich to do LL with Stryde. Many women complain because they don't have 3-4.000 euro to do a boobjob, which is an easy surgery with great results amd we must pay 50.000+ euro to break our bones, harming our athletic abilities by some percentage (from a few to too much) and facing many risks and pain for months.
Yes, life is unfair. But still, LL makes it more fair but with a high price in money and risks.
Hi Body Builder
You are absolutely right about all those thing!!  I think that Stryde will be the best option for a long time with some minor upgrades over time.  SYNOSTE Nitinail is pretty much the same as Stryde with some upgrades.  Hopefully, it can bring down the price at least.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Drop-Loud on September 08, 2020, 01:11:29 PM
Hi Everyone,

According to this guy, LPP (Link protein N-terminal peptide) could be a game changer for people with closed growth plates

https://www.reddit.com/r/looksmaxxing/comments/hmj34y/what_future_heightmaxxing_regimen_may_look/

https://www.hindawi.com/journals/sci/2018/3217895/

https://onlinelibrary.wiley.com/doi/abs/10.1002/1529-0131(199801)41:1%3C157::AID-ART19%3E3.0.CO;2-J


https://www.tapatalk.com/groups/lsjl/we-are-getting-close-to-reopening-growth-plates-t1023-s70.html


Concerning Indirubin, CK Biotechnology Co. (Seoul, KR) filed a patent for a PHARMACEUTICAL COMPOSITION CONTAINING INDIRUBIN DERIVATIVE AS ACTIVE INGREDIENT :

https://www.freepatentsonline.com/y2020/0223824.html

I tried to contact them, but did not received any answer : http://ckbiotech.co.kr/company/locationcontact/

Can you try to reach them? Maybe you will have more luck
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: F_99 on September 08, 2020, 01:21:45 PM
Hi Everyone,

According to this guy, LPP (Link protein N-terminal peptide) could be a game changer for people with closed growth plates

https://www.reddit.com/r/looksmaxxing/comments/hmj34y/what_future_heightmaxxing_regimen_may_look/

https://www.hindawi.com/journals/sci/2018/3217895/

https://onlinelibrary.wiley.com/doi/abs/10.1002/1529-0131(199801)41:1%3C157::AID-ART19%3E3.0.CO;2-J


https://www.tapatalk.com/groups/lsjl/we-are-getting-close-to-reopening-growth-plates-t1023-s70.html


Concerning Indirubin, CK Biotechnology Co. (Seoul, KR) filed a patent for a PHARMACEUTICAL COMPOSITION CONTAINING INDIRUBIN DERIVATIVE AS ACTIVE INGREDIENT :

https://www.freepatentsonline.com/y2020/0223824.html

I tried to contact them, but did not received any answer : http://ckbiotech.co.kr/company/locationcontact/

Can you try to reach them? Maybe you will have more luck

You from tapatalk/lsjl group forum?
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Body Builder on September 08, 2020, 01:59:13 PM
Again, no one can predict the future. But the question in the post was also "What do you hope to see happen?"

If a non invasive alternative will come out and be available on the market, you're free to go to support those millionaire NW($) orthopedic surgeons.
For the next 30 years a non invasive method to become taller is impossible.
Moreover in the next 10 years were me and most of us here are willing to do another LL.
I don't care what will happen when I am 60yo, height matters when looks really matters, till 45-50 yo at max.
So for me and all of us here, stryde (or a full weight bearing internal nail in genera) is the best we would have as a method to do LL.
Everything else is delusional, at least for us.

I am not talking theoritical about LL like most people here, I am a veteran who needs to get things done. So talking about the long future is futile, everyone should care about the best option of LL to make it happen.
And I guarantee you that there will not be a non invasive method to get taller for the next many years, when we are not old men.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: F_99 on September 08, 2020, 02:03:09 PM
For the next 30 years a non invasive method to become taller is impossible.
Moreover in the next 10 years were me and most of us here are willing to do another LL.
I don't care what will happen when I am 60yo, height matters when looks really matters, till 45-50 yo at max.
So for me and all of us here, stryde (or a full weight bearing internal nail in genera) is the best we would have as a method to do LL.
Everything else is delusional, at least for us.

I am not talking theoritical about LL like most people here, I am a veteran who needs to get things done. So talking about the long future is futile, everyone should care about the best option of LL to make it happen.
And I guarantee you that there will not be a non invasive method to get taller for the next many years, when we are not old men.

No, you can't.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Drop-Loud on September 08, 2020, 05:05:20 PM
I'm one of the member. We do our best to find non invasive techniques to grow taller. But I'em not an expert. I don't understand very much what is written in all theses studies. I think we are close to find an alternative way to grow taller.

Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Hagane on September 08, 2020, 05:30:42 PM
the issue with finding a drug to make you grow taller is all the loopholes you have to go through to get it approved
"The average time from FDA application to approval of drugs is 12 years, and the estimated average cost of taking a new drug from concept to market exceeds $1 billion."(1)
so bodybuiler is technically not wrong, im not gonna argue that theres no market for it ( obvs there is ) but my guess is if somehow they manage to approve it the target will be pediatric first. then youll encounter the issue of doctors gatekeeping and not rx it for cosmetic reasons.







1.Van Norman, G. A. (2016). Drugs, devices, and the FDA: part 1: an overview of approval processes for drugs. JACC: Basic to Translational Science, 1(3), 170-179.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: .. on September 08, 2020, 05:35:37 PM
People who have done or are set to do LL will say that no alternative will be possible.

Not saying I know, but there was a poster named 'extremis' here a while back who appears to be more intelligent and knowledgeable in this field than any of us saying that the cure would be possible in the near future.

Anyone can read his argument here: http://www.limblengtheningforum.com/index.php?topic=9352.0
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: F_99 on September 08, 2020, 06:23:49 PM
I'm one of the member. We do our best to find non invasive techniques to grow taller.

Yeah, especially MiniGolfer/Tyler and Oepsilon seem to know what they're talking about. If only that immature kid, Srtike_Poseidon would shut up.

Quote
But I'em not an expert. I don't understand very much what is written in all theses studies. I think we are close to find an alternative way to grow taller.

Same. I'm in the programming/math field and don't know much about these.
I just want a safe method to become taller, because LL surgery at the moment, is not. I don't want to walk like a grandpa for the rest of my life with premature arthritis and constant pain, but I also don't want to take possibly harmful drugs and get cancer or whatever issue.
I wanted to ask you something because you are at LSLJ forum, but I forgot what.

I chatted with this guy Polynomality who wrote this post
https://www.reddit.com/r/looksmaxxing/comments/hmj34y/what_future_heightmaxxing_regimen_may_look/
They'll do some experiments with rats I think.
If it works on humans safely the height increasing problem will be gone and so will our height neurosis and misery, spending our time searching for a fking solution.
But it's a tough nut to crack. LL surgery (cosmetic, deformity and discrepancy correction) is a billion/yr dollar bussiness.

People who have done or are set to do LL will say that no alternative will be possible.

Yeah, like BB for example, because the thought of wasting money for a painful, risky, permanently damaging, time consuming procedure, that they could have avoided if only they waited for an alternative a few years more, scares them. I'm sure LL surgeons will say that no alternative will be possible too.
This is a limb lenghtening forum, and if it's possible to lengthen your legs without surgery, you should look forward to that, is what they don't understand.

the issue with finding a drug to make you grow taller is all the loopholes you have to go through to get it approved
"The average time from FDA application to approval of drugs is 12 years, and the estimated average cost of taking a new drug from concept to market exceeds $1 billion."(1)
so bodybuiler is technically not wrong, im not gonna argue that theres no market for it ( obvs there is ) but my guess is if somehow they manage to approve it the target will be pediatric first. then youll encounter the issue of doctors gatekeeping and not rx it for cosmetic reasons.







1.Van Norman, G. A. (2016). Drugs, devices, and the FDA: part 1: an overview of approval processes for drugs. JACC: Basic to Translational Science, 1(3), 170-179.



"Man won't fly for a million years"

-The New York Times, 1903.
https://www.reddit.com/r/todayilearned/comments/742lx4/til_that_in_1903_the_new_york_times_predicted/
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: ghkid2019 on September 08, 2020, 06:33:47 PM
Honestly we will get stem cell > growth plate implantation (surgery needed) before we get something that can regrow a growth plate with injections or meds.

I would be very down to do a growth plate implantation tho. It will still probably require a fracture and to some people that's still as barbaric as regular LL
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: .. on September 08, 2020, 06:56:13 PM
Yeah, especially MiniGolfer/Tyler and Oepsilon seem to know what they're talking about. If only that immature kid, Srtike_Poseidon would shut up.

Same. I'm in the programming/math field and don't know much about these.
I just want a safe method to become taller, because LL surgery at the moment, is not. I don't want to walk like a grandpa for the rest of my life with premature arthritis and constant pain, but I also don't want to take possibly harmful drugs and get cancer or whatever issue.
I wanted to ask you something because you are at LSLJ forum, but I forgot what.

I chatted with this guy Polynomality who wrote this post
https://www.reddit.com/r/looksmaxxing/comments/hmj34y/what_future_heightmaxxing_regimen_may_look/
They'll do some experiments with rats I think.
If it works on humans safely the height increasing problem will be gone and so will our height neurosis and misery, spending our time searching for a fking solution.
But it's a tough nut to crack. LL surgery (cosmetic, deformity and discrepancy correction) is a billion/yr dollar bussiness.

Yeah, like BB for example, because the thought of wasting money for a painful, risky, permanently damaging, time consuming procedure, that they could have avoided if only they waited for an alternative a few years more, scares them. I'm sure LL surgeons will say that no alternative will be possible too.
This is a limb lenghtening forum, and if it's possible to lengthen your legs without surgery, you should look forward to that, is what they don't understand.


"Man won't fly for a million years"

-The New York Times, 1903.
https://www.reddit.com/r/todayilearned/comments/742lx4/til_that_in_1903_the_new_york_times_predicted/

That Srtike_Poseidon totally got me fooled lol

By the way, didn't Teplyashin already find an alternative but couldn't make it to clinical trial: http://www.naturalheightgrowth.com/2016/04/30/big-updates-stem-cell-height-increase-research-done-russia-alexander-teplyashin-plastic-surgery-clinic/?

Perhaps, there has been some progress on this.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Drop-Loud on September 08, 2020, 11:13:52 PM
I think LPP (Link protein N-terminal peptide) and Indirubin are the most promising compound actually. We need more testing on rats/rabbits to make sure it's safe for humans. According to the patent of the Korean company, their Indirubin composition should be safe. I don't if LPP is safe. Some people want to try LPP on themselves, but I think we need more trials on rats/rabbits.

Another great website : http://www.naturalheightgrowth.com/

There is relaxin that may work too according to this patent : https://patents.google.com/patent/US20060052304A1/en

Long time ago, I also found a patent for an LSJL device that could help people grow taller, but I can't find it anymore.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: ghkid2019 on September 08, 2020, 11:42:19 PM
Can someone tldr TPP. How does it reopen, let's say, a completely fused growth plate that has completely ossified and the person is like 35 years old already. Wouldn't there be literally 0 cartilage in the "growth plates" area, it ossified decade ago
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: F_99 on September 09, 2020, 03:24:39 PM
I think LPP (Link protein N-terminal peptide) and Indirubin are the most promising compound actually.

Yeah, C16H10N2O2 + LPP look promising.

I told the reddit looksmaxxing post guy, he's a biohacker, to visit this forum here and explain what's up a bit further, but he said
"Once we find what works, we might go there to tell our experiences."

Quote
We need more testing on rats/rabbits to make sure it's safe for humans.

Meh, even then we won't know if it's 100% safe I guess, but at this point..

Quote
According to the patent of the Korean company, their Indirubin composition should be safe. I don't if LPP is safe. Some people want to try LPP on themselves, but I think we need more trials on rats/rabbits.

Another great website : http://www.naturalheightgrowth.com/

There is relaxin that may work too according to this patent : https://patents.google.com/patent/US20060052304A1/en

Ever heard (anything) about this?
http://www.limblengtheningforum.com/index.php?topic=65449.0

Another one (I don't know if this can be applied for cartilage regeneration/regrowth, etc.)
https://www.reddit.com/r/Futurology/comments/ip7hnz/new_molecule_repairs_cartilage_and_relieves/

Quote
Long time ago, I also found a patent for an LSJL device that could help people grow taller, but I can't find it anymore.

Tyler is working on a "new" LSJL method now, by the way, right?
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Drop-Loud on September 09, 2020, 05:00:20 PM
I've heard about c60 fullerene before. I think it's an anti aging molecule that you can find in some Olive Oil. One guy sais he grow taller with. I think C60 is safe and we can find it on amazon. I don't know what is the right dosage and how much you can grow with that. I don't know if everyone will be able to grow with C60, but it's something we can try.

Tyler said he is working on a "new" LSJL method. He sais that on the "LSJL forum" and "natural height growth" website.

It's cool if the biohacker from "reddit looksmaxxing" could join us. We should all join our forces to find a solution to grow taller the safest way possible, without surgery.

We should look for help in the biohaking world. Some biohackers have a background in the field of biology/biotechnology.

I heard people who said they grew taller with the power of they mind. I don't know if it's possible or not, but I found the story of a guy that is quite intriguing : https://www.youtube.com/watch?v=PdhB9RzDG_w

https://www.youtube.com/watch?v=fkrp7tffYWc
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: F_99 on September 09, 2020, 05:55:17 PM
I don't know what is the right dosage and how much you can grow with that. I don't know if everyone will be able to grow with C60, but it's something we can try.

I personally found this from r/longevity. He mentions the dosage, I think, and looks like that he knows what he's talking about. This forum (LongeCity) is a serious one, with 40, 50, 60 yr-old biohackers/biologists that contact with/are themselves researchers who work in the anti-aging field. These guys question everything, even aging and biological death like Aubrey De Grey, David Sinclair, etc.
Like their mindset.

Maybe I should start taking c60, tbh.

Quote
I heard people who said they grew taller with the power of they mind.

I've heard jokes too.

Quote
It's cool if the biohacker from "reddit looksmaxxing" could join us. We should all join our forces to find a solution to grow taller the safest way possible, without surgery.

+1
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: ghkid2019 on September 09, 2020, 06:22:35 PM
We got all dese armchair scientists from reddit beddit  tit but no one answering:

Can someone tldr TPP. How does it reopen, let's say, a completely fused growth plate that has completely ossified and the person is like 35 years old already. Wouldn't there be literally 0 cartilage in the "growth plates" area, it ossified decade ago
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: F_99 on September 09, 2020, 06:26:32 PM
You can ask him yourself.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: ghkid2019 on September 09, 2020, 07:18:16 PM
I asked him and all he said was ask o99 . Whatever idc anymore fk dis shiet
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: F_99 on September 09, 2020, 07:20:03 PM
I asked him and all he said was ask o99 . Whatever idc anymore fk dis shiet


Lol, he didn't chat with my u/O_99 account but with a throwaway one with a different name (I have RL friends that use reddit too so I created another one..)

u/ghkid2019?
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Body Builder on September 09, 2020, 08:34:37 PM
No, you can't.
There were 60 years from external Ilizarovs to a full weight bearing magnrtic internal nail.
If you think that in less than 30 years there will be a non invasive alternative to get taller then wait for it.
You will just become an old man waiting for nothing.

Personally I am not delusional and know that there wont be a non invasive akternative at least till I get old.
You can't wait by leting your life pass as being short for a delusion, not my problem.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Drop-Loud on September 09, 2020, 10:29:40 PM
c60 could be a good way to start. It should be safe and easy to find. + it's anti aging.

I'd love to have a response from the Korean Company about their indirubin solution, but unfortunately they don't respond to my emails.

A guy called Harald Oberländer was in contact with universities that were working on research projects that could increase the height of adults.  He was looking for money, but didn't want to talk much about it because of "confidential agreements". People want to know where they put their money.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: ghkid2019 on September 09, 2020, 10:34:26 PM

Lol, he didn't chat with my u/O_99 account but with a throwaway one with a different name (I have RL friends that use reddit too so I created another one..)

u/ghkid2019?

Nah I'm just playin haha my fault.

Can I ask you one question. Are you considering LL at all? Or will you hold out for new technology? Assuming the tech never comes in 20-30 years (I hope this doesn't happen either), would you consider LL with stryde? If you knew that this was the best thing we had for 20-39 years

Thank you
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: F_99 on September 10, 2020, 08:22:55 AM
There were 60 years from external Ilizarovs to a full weight bearing magnrtic internal nail.

And there were 6 million years in human history that we didn't have doctors.

Personally I am not delusional and know that there wont be a non invasive akternative at least till I get old.
You can't wait by leting your life pass as being short for a delusion, not my problem.

You are delusional because you think you can predict the future. Go pay 30, 40, 50 grand a surgeon to break your legs again to become 180cm+ and don't look for alternatives.
Buy a fancy walking stick too, you might need it, afterwards.

A guy called Harald Oberländer was in contact with universities that were working on research projects that could increase the height of adults.  He was looking for money, but didn't want to talk much about it because of "confidential agreements". People want to know where they put their money.

Didn't know that. Interesting. Got any links?

Are you considering LL at all? Or will you hold out for new technology?

Yea, I'm considering (non-invasive) Limb Lengthening. Not the surgery (at the moment, at least).

Assuming the tech never comes in 20-30 years (I hope this doesn't happen either), would you consider LL with stryde? If you knew that this was the best thing we had for 20-39 years

Then I'm f****d. Idrk, tbh.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: .. on September 10, 2020, 09:48:33 AM
And there were 6 million years in human history that we didn't have doctors.

You are delusional because you think you can predict the future. Go pay 30, 40, 50 grand a surgeon to break your legs again to become 180cm+ and don't look for alternatives.
Buy a fancy walking stick too, you might need it, afterwards.

Didn't know that. Interesting. Got any links?

Yea, I'm considering (non-invasive) Limb Lengthening. Not the surgery (at the moment, at least).

Then I'm f****d. Idrk, tbh.

http://www.limblengtheningforum.com/index.php?topic=5139.0

http://jrscience.wcp.muohio.edu/Research/HNatureProposalsArticles/Therecouldbeasafeandeffec.html

What is your height, age and country?
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: F_99 on September 10, 2020, 11:12:28 AM
What is your height, age and country?

Current height 172*, wingspan 175-176.

I'm actually 21

I'm in Greece so I'd say out of my country, used Ferrari/House priced Paley.

Why does it matter though?

http://www.limblengtheningforum.com/index.php?topic=5139.0

That Body Builder guy even at that thread there, 2+ years ago, was replying "No alternative will happen for the next many years". Smh

A guy called Harald Oberländer was in contact with universities that were working on research projects that could increase the height of adults.

You know anything about those research projects? Or even that's a scam 100%?
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: .. on September 10, 2020, 11:18:33 AM
Why does it matter though?

So you are not so short and you have more time to wait than me and many others.

That Body Builder guy even at that thread there, 2+ years ago, was replying "No alternative will happen for the next many years". Smh

In fairness, he's been right so far until we prove otherwise.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: F_99 on September 10, 2020, 11:22:14 AM
In fairness, he's been right so far until we prove otherwise.

"So far". Like 3 years, making predictions for decades.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Drop-Loud on September 10, 2020, 07:56:37 PM
This is all I found about Harald Oberländer

http://www.naturalheightgrowth.com/2013/01/05/harald-from-biomedical-growth-research-initiative-bgri-answers-questions/

http://jrscience.wcp.miamioh.edu/Research/HNatureProposalsArticles/Therecouldbeasafeandeffec.html

http://www.growthresearch.org/aims.htm

I don't really know if he is very serious or if it's a scam.


There was this russian scientist who used stem cells to make a sheep grow taller,  but he has to stop his research if I'm right,  because of Russian regulations.

http://www.naturalheightgrowth.com/2014/11/01/video-alexander-teplyashins-laboratory-lengthening-legs-sheep-using-stem-cell-implants/

http://www.naturalheightgrowth.com/2016/04/30/big-updates-stem-cell-height-increase-research-done-russia-alexander-teplyashin-plastic-surgery-clinic/

http://www.naturalheightgrowth.com/2016/10/26/alexander-teplyashins-research-increases-length-finger-bone/

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(05)74795-4/fulltext

Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Body Builder on September 10, 2020, 08:56:34 PM
And there were 6 million years in human history that we didn't have doctors.

You are delusional because you think you can predict the future. Go pay 30, 40, 50 grand a surgeon to break your legs again to become 180cm+ and don't look for alternatives.
Buy a fancy walking stick too, you might need it, afterwards.

Didn't know that. Interesting. Got any links?

Yea, I'm considering (non-invasive) Limb Lengthening. Not the surgery (at the moment, at least).

Then I'm f****d. Idrk, tbh.
I am not taking advice from someone who waits for a miracle to think about LL.
Even with a second LL I will be much better from a moaning man who thinks that with a pill he would become 6ft.

LL is for strong and determined men.
You have nothing in common with them.
You can of course become a guinea pig and try experiments od scam doctors who may think are better than the real way to go.
But as I said, you are just an 20yo kid. Who cares.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Body Builder on September 10, 2020, 08:59:36 PM
So you are not so short and you have more time to wait than me and many others.

In fairness, he's been right so far until we prove otherwise.
No need to answer to kids who think that with a pill they will have the height they want.
They are so delusional that it is really funny.
They are here for fun, they won't ever do LL because it need guts and determination.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: .. on September 11, 2020, 06:46:00 AM
No need to answer to kids who think that with a pill they will have the height they want.
They are so delusional that it is really funny.
They are here for fun, they won't ever do LL because it need guts and determination.

Hi BB. I'm also looking for such a pill.

Not a literal pill, but certainly a non-invasive and non-crippling form of height increase method.

Let's face it. We both don't understand much about science especially compared to 'extremis" and he said 2 years ago it's possible if only we give more attention into this field.

Tbh I don't understand much about his scientific theory, but I can confirm his theories regarding human attraction, psychology, etc.

It may or may never come. But the best we can do at the moment is to help the researches and spread information.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: F_99 on September 11, 2020, 08:25:05 AM
I am not taking advice from someone who waits for a miracle to think about LL.

I'm not waiting a miracle. I haven't even completely ruled out the surgery yet for the future.
There wasn't any advice at all. Learn a few more English words.

Quote
LL is for strong and determined men.
You have nothing in common with them.

Today I learned that LL isn't for women, and men who decide not to do LL, are weak and undetermined.
Maybe they don't have the money. Or don't want premature arthritis. Or don't want constant pain for the rest of their life. Or don't want to walk like a grandpa for the rest of their life. Or want to be able to play sports and run. Or don't want to die. http://www.limblengtheningforum.com/index.php?topic=8978.0   
http://www.limblengtheningforum.com/index.php?topic=64405.0

You know nothing about strong men.

Quote
You can of course become a guinea pig and try experiments od scam doctors who may think are better than the real way to go.
But as I said, you are just an 20yo kid. Who cares.

Most short people want leg lenthening surgery alternatives, and why are you in this thread arguing anyway? It's about the future. Go do your second LLS if you are so sure.

Quote
No need to answer to kids who think that with a pill they will have the height they want.
They are so delusional that it is really funny.

Says the guy who thinks he can predict what will happen 30+ years from now, in a field that he knows nothing about.

From your other posts it's clear that you are delusional..

"women mostly/only care about height" regardless of height range, "people with guts do LL", and not so recent ones, "modern boys are sissies", calling other people "stupid virgins", "completely useless", "incels like you are worthless", because they have different opinions from you, 'gems' like this
"Real men don't care about women that alrrady have children.
Only a beta sissy like you would care.", etc.
All that and many more 'gems' are on your profile <posts>.

..and that height wasn't (and isn't) your only problem;


End of the discussion.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Kenda on September 11, 2020, 01:41:06 PM
c60 could be a good way to start. It should be safe and easy to find. + it's anti aging.

I'd love to have a response from the Korean Company about their indirubin solution, but unfortunately they don't respond to my emails.

A guy called Harald Oberländer was in contact with universities that were working on research projects that could increase the height of adults.  He was looking for money, but didn't want to talk much about it because of "confidential agreements". People want to know where they put their money.


what even is C60 ?? can you explain further please
if my growth plates fused 5 years ago, whats the point of taking a drug when the Bone Maker "Growth plates" are fused into rock solid bone >.<
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: F_99 on September 11, 2020, 01:43:21 PM

what even is C60 ?? can you explain further please
if my growth plates fused 5 years ago, whats the point of taking a drug when the Bone Maker "Growth plates" are fused into rock solid bone >.<

We don't know if it works.
http://www.limblengtheningforum.com/index.php?topic=65449.0
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Drop-Loud on September 11, 2020, 11:45:59 PM
More info about C60 fullerene here : http://www.naturalheightgrowth.com/2020/07/04/can-c60-fullerene-make-taller/

Their conclusion :

The results on fullerene are inconclusive as we can’t be sure how the individual got the height(articular cartilage growth or increase in bone length?) and whether the height was due to reduced cartilage catabolism or due to stem cell proliferation.  And there’s not enough human studies.  One inch isn’t a lot to get excited about either.

https://core.ac.uk/download/pdf/206760033.pdf

https://www.oarsijournal.com/article/S1063-4584(15)01049-3/fulltext

https://www.purehimalayanshilajit.com/carbon-60/

https://www.longecity.org/forum/topic/100363-stem-cell-self-renewal-with-c60/

Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Drop-Loud on September 11, 2020, 11:50:15 PM
My opinion is that we have nothing to lose at trying C60.

We need to do exactly what the guy did here : https://www.longecity.org/forum/topic/100363-stem-cell-self-renewal-with-c60/
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: ghkid2019 on September 11, 2020, 11:56:08 PM
Hopefully it's not toxic or we buy an impure source then
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: las vegas baby on September 12, 2020, 12:21:50 PM
I hope that

- a limb length surgeon gets this procedure done for himself publicly
- media covers this news extensively
- it shows "skin in the game" of surgeons in the procedure
- shows that normal successful people (like a well trained well off surgeon with a family) can get it safely and break stigma of leg length surgery   
- people stop being ashamed of it
- there is more freely flowing information about the surgery, doctors and experiences
- industry becomes regulated. fraud doctors are called out
- surgery also becomes cheaper
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Drop-Loud on September 12, 2020, 01:07:14 PM
I we should buy a productu similare to this one :

https://www.myvitalc.com/ess60-c60-olive-oil-hy/ref/21/
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: F_99 on September 12, 2020, 02:16:57 PM
I we should buy a productu similare to this one :

https://www.myvitalc.com/ess60-c60-olive-oil-hy/ref/21/

Drop-Loud,
If you find new information about c60 I think it's better to post it here http://www.limblengtheningforum.com/index.php?topic=65449.0
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Drop-Loud on September 12, 2020, 06:11:44 PM
Ok, I'll do that O_99.

I talked with the guy who wrote the reddit post "What Future Heightmaxxing Regimen May Look" and he said that the patent of the Korean company is trying to accomplish the exact same thing than his stack. According to the Korean company, their compound should be safe.

We need to find a way to contact them to see when their drug will be available. They did not answered my message. Maybe the contact page do not work, I don't know.

https://www.freepatentsonline.com/y2020/0223824.html
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Antoine on September 12, 2020, 10:49:40 PM
Ok, I'll do that O_99.

I talked with the guy who wrote the reddit post "What Future Heightmaxxing Regimen May Look" and he said that the patent of the Korean company is trying to accomplish the exact same thing than his stack. According to the Korean company, their compound should be safe.

We need to find a way to contact them to see when their drug will be available. They did not answered my message. Maybe the contact page do not work, I don't know.

https://www.freepatentsonline.com/y2020/0223824.html

Thank you for this. However, isn’t LPP peptide a fundamental part of his stack? It isn’t included in the Korean compound. I guess it should be injected, isn’t it?
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Drop-Loud on September 12, 2020, 11:03:51 PM
You're welcome. Yes, his stack includes LPP and it's the main components I think for adults. That's what he answered me :

They're trying to replicate what the heightmaxxing stack is trying to accomplish.

    The composition [(the ingredients of this operation)] is characterized by promoting the proliferation of chondrocytes, differentiation of osteoblasts by activating Wnt/β-catenin signaling via stabilization and nuclear localization of β-catenin in osteoblasts



He said LPP would need to be injected. 650-800ng per dose. How many doses needed? He do not know. Is it safe for humans now? I don't know. I must say all these studies are a bit complex to understand.

The Korean compound should be safe according to them.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: ghkid2019 on September 12, 2020, 11:10:37 PM
Very good research sir. Appreciate the work
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Antoine on September 12, 2020, 11:52:26 PM
You're welcome. Yes, his stack includes LPP and it's the main components I think for adults. That's what he answered me :

They're trying to replicate what the heightmaxxing stack is trying to accomplish.

    The composition [(the ingredients of this operation)] is characterized by promoting the proliferation of chondrocytes, differentiation of osteoblasts by activating Wnt/β-catenin signaling via stabilization and nuclear localization of β-catenin in osteoblasts


He said LPP would need to be injected. 650-800ng per dose. How many doses needed? He do not know. Is it safe for humans now? I don't know. I must say all these studies are a bit complex to understand.

The Korean compound should be safe according to them.

Thank you very much, I appreciate it too. But how can the Korean compound replicate the heightmaxxing stack if the filing date of the Korean patent is 04/10/2018 while the reddit post “What Future Heightmaxxing Regimen May Look” was written little more than two months ago?
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Drop-Loud on September 13, 2020, 12:41:25 AM
You're all very welcome. Honestly, I don't know. That's what the author of the reddit post told me. I don't understand very much all the technical stuff he is talking about. I just shared what he said.

We should focus on his research and the drug of the Korean company too to see what works best.

It's possible to contact him here : https://www.reddit.com/r/looksmaxxing/comments/hmj34y/what_future_heightmaxxing_regimen_may_look/

I think we should invite him to join us here
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Drop-Loud on September 13, 2020, 01:57:28 AM
Another interesting link : http://www.naturalheightgrowth.com/2020/08/29/new-lsjl-paper-update-revising-lsjl-method/
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: F_99 on September 13, 2020, 08:07:27 AM
Very interesting stuff, Drop-Loud.
However, I told the reddit looksmaxxing post guy to come over here and explain what's going on, but he said if we find that it works, we might go there to tell our experiences.
Have you tried lsjl at all?
I'll definetely try this revised lsjl method, after I stop wearing shorts, in order to avoid the -what are these marks/bruises on your legs- questions. I'll do the clamping, weight loading, etc.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Antoine on September 13, 2020, 11:16:09 AM
You're all very welcome. Honestly, I don't know. That's what the author of the reddit post told me. I don't understand very much all the technical stuff he is talking about. I just shared what he said.

We should focus on his research and the drug of the Korean company too to see what works best.

It's possible to contact him here : https://www.reddit.com/r/looksmaxxing/comments/hmj34y/what_future_heightmaxxing_regimen_may_look/

I think we should invite him to join us here

I think it too. I don’t have a reddit account though. The issue with this stack is that LPP is needed and we don’t know how to get it or if it’s safe.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Michael J. Assayag, MD on September 13, 2020, 12:55:29 PM
The future of limb lengthening will be industry driven. With implants allowing more mechanical abilities to walk without compromising quality of regenerate. Medications are unfortunately not going to make bones taller without having tremendous effects on other organs.

Here is my take on the future of Cosmetic Limb Lengthening:

As more reliable , accurate, weight bearing  limb lengthening implants flood the market, The overall cost of implant will tremendously decrease, and by corollary the cost of procedure.

Rehabilitation protocoles will become streamlined and will allow for more normal living during the process.

More surgeons will become trained in the field  and the process will become so affordable that it will be mainstream, similar to the way breast augmentations and rhinoplasty are mainstream.


Dr. Michael J. Assayag, MD. FRCSC
Limb Lengthening and Reconstruction Surgeon
International Center for Limb Lengthening of Baltimore
http://www.heightrx.com
https://www.limblength.org/conditions/short-stature/
massayag@lifebridgehealth.org
@bonelengthening on Instagram
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: F_99 on September 13, 2020, 12:59:24 PM
The future of limb lengthening will be industry driven. With implants allowing more mechanical abilities to walk without compromising quality of regenerate. Medications are unfortunately not going to make bones taller without having tremendous effects on other organs.

Here is my take on the future of Cosmetic Limb Lengthening:

As more reliable , accurate, weight bearing  limb lengthening implants flood the market, The overall cost of implant will tremendously decrease, and by corollary the cost of procedure.

Rehabilitation protocoles will become streamlined and will allow for more normal living during the process.

More surgeons will become trained in the field  and the process will become so affordable that it will be mainstream, similar to the way breast augmentations and rhinoplasty are mainstream.


Dr. Michael J. Assayag, MD. FRCSC
Limb Lengthening and Reconstruction Surgeon
International Center for Limb Lengthening of Baltimore
http://www.heightrx.com
https://www.limblength.org/conditions/short-stature/
massayag@lifebridgehealth.org
@bonelengthening on Instagram

So you are an actual MD, right?
I understand that you're focused on CLL, but if you could give a honest answer;
What's your take on those hypothetical surgery alternatives mentioned above in this thread?
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Drop-Loud on September 13, 2020, 01:02:32 PM
Hi O_99,

I never tried LSJL to be honest. I was more looking at possible compounds that could help use grow taller. I will see if I can find again the patent of the Japanese lab/company who built an LSJL device that was supposed to help people grow taller. Maybe we can try to build one?


Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: F_99 on September 13, 2020, 01:04:31 PM
Hi O_99,

I never tried LSJL to be honest. I was more looking at possible compounds that could help use grow taller. I will see if I can find again the patent of the Japanese lab/company who built an LSJL device that was supposed to help people grow taller. Maybe we can try to build one?

Hey.
But how? Are you a Mechanical Engineer?
Haven't Tyler been using a LSJL 'purpose' device?
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Drop-Loud on September 13, 2020, 01:08:19 PM
Hi Antoine,

Some peeptide manufacturers I think will be able to produce it, but I'm 100% sure they wont sell it to private individuals. In general, they work with pharmaceutical and biotechnology companies, colleges, universities, medical research institutions....

Maybe some manufacturers in India or China would sell to private individuals, but is it safe? That's a big question.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Drop-Loud on September 13, 2020, 01:12:10 PM
No, I work in the field of network computing. But with the help of fab labs, or people here who work in the field of mechanical engineering, it should not be too difficult I think.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Michael J. Assayag, MD on September 13, 2020, 01:27:15 PM
So you are an actual MD, right?
I understand that you're focused on CLL, but if you could give a honest answer;
What's your take on those hypothetical surgery alternatives mentioned above in this thread?

I am an orthopedic surgery. My focus is actually limb lengthening and deformity reconstruction. CLL being simply one part of what I do.

As for my take on lateral synovial joint loading. I could not find a single study discussing the method. It speaks for itself... we should believe in science of limb lengthening. Not witchcraft.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: F_99 on September 13, 2020, 01:41:30 PM
I am an orthopedic surgery. My focus is actually limb lengthening and deformity reconstruction. CLL being simply one part of what I do.

Yeah. Meant LL.

As for my take on lateral synovial joint loading. I could not find a single study discussing the method. It speaks for itself... we should believe in science of limb lengthening. Not witchcraft.

There were and some other possible future solutions mentioned in this thread, not only LSJL, but I imagine that I'd receive the witchcraft answer for those as well.

No, I work in the field of network computing. But with the help of fab labs, or people here who work in the field of mechanical engineering, it should not be too difficult I think.

I'm a programmer, so not sure how can I help.
What do you have in mind? A ball pein hammer mimicking device for tapping? Did you ask Tyler about this?
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Drop-Loud on September 13, 2020, 01:55:23 PM
I found this, but can't find the other patent now : http://www.naturalheightgrowth.com/wp-content/uploads/2013/12/Yokota-LSJL-Machine.pdf
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Drop-Loud on September 13, 2020, 01:59:41 PM
That's science Doctor Michael :

https://www.freepatentsonline.com/y2020/0223824.html
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: ghkid2019 on September 13, 2020, 02:01:51 PM
Lsjl lol. Grow 0.5 cm after a year of clamping bone
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Michael J. Assayag, MD on September 13, 2020, 02:04:33 PM
Yeah. Meant LL.

There were and some other possible future solutions mentioned in this thread, not only LSJL, but I imagine that I'd receive the witchcraft answer for those as well.


Well, the problem is feasibility of reopening growth plates. It sounds good on paper.

However closed growth plates are virtually indistinguishable from regular bone. Reopening growth plates is for now, an impossibility. I’d be highly surprised to see such a technology in the future. We do use for some medical conditions, medications that delay growth plate closures.


You made an interesting point earlier: I could buy a house or a used ferrari for the cost of going to Paley and Guichet. It is true (at least for now) However the height gains made from LL will never need revision once bone has healed. The house will always need more upkeep, so does the ferrari. Height is forever. (until we start shrinking from disc degeneration :p)



Drop Loud: that’s a patent application. There’s a long way to go until any such thing hits the market . To be continued.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: F_99 on September 13, 2020, 02:06:21 PM
Well, the problem is feasibility of reopening growth plates. It sounds good on paper.

However closed growth plates are virtually indistinguishable from regular bone. Reopening growth plates is for now, an impossibility. I’d be highly surprised to see such a technology in the future. We do use for some medical conditions, medications that delay growth plate closures.


You made an interesting point earlier: I could buy a house or a used ferrari for the cost of going to Paley and Guichet. It is true (at least for now) However the height gains made from LL will never need revision once bone has healed. The house will always need more upkeep, so does the ferrari. Height is forever. (until we start shrinking from disc degeneration :p)



Drop Loud: that’s a patent application. There’s a long way to go until any such thing hits the market . To be continued.

Alright. Thanks for answering.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: ghkid2019 on September 13, 2020, 02:11:15 PM
Ppl be like, we take drug, turn bone into ephyphiseal cartilage.

Your whole skeleton is bone. So anything that turns bone into ephyphiseal cartilage will turn ur whole fukin body into cartilage.

Dis   will never work. Everything is coping mechanism. Lsjl is fkin cope.
"Muh local injection" no, inject ur whole leg stick a 20g syringe boom ciao my as

Closest thing we haf in future will be osteotomy in one segment of bones, implant stem cell that turn into growth plates, heal and rehab for a month or two until implant is connected with bone, give hgh to the guy and run an aromatase Inhibitor and boost the growth plate rate with other drugs.

We did dis with sheep already. This is still breaking ur legs, will still be a traumatic surgery. But faster and more natural process hopefurry. But still a fkin traumatic surgery and expect to be hospitalized for days and do alot of rehab just like regular LL

nuts to think u can fkin reopen ossified indistinguished bone and turn it SELECTIVELY back to cartilage.

@Bonelengthening ig doctor michael assayag is right. He is a veteran of this forum. He has help us many time. Why doubt credentials of this guy, some of u are legit 2 weeks old account. Doubtin credentials mf
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: F_99 on September 13, 2020, 02:19:10 PM
@Bonelengthening ig doctor michael assayag is right. He is a veteran of this forum. He has help us many time. Why doubt credentials of this guy, some of u are legit 2 weeks old account. Doubtin credentials mf

What are you talking about
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: .. on September 13, 2020, 03:59:55 PM
This Assayag Doctor already said that his focus is limb lengthening. Like Paley, he wouldn't want any other technologies replacing it.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: a on September 13, 2020, 04:04:33 PM
Bro ghkid, the thing I don't understand is whether the stem cell surgery would happen for all the segments of your leg or just one segment (both femur or both tibs)

And is it going to grow a new tissue simultaneously etc? That's what you mean by natural?
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Michael J. Assayag, MD on September 13, 2020, 04:30:55 PM
This Assayag Doctor already said that his focus is limb lengthening. Like Paley, he wouldn't want any other technologies replacing it.


Quite the contrary, I’d love to see better, easier technology. I just question the feasibility behind it. Nature is still better than us... But I would love to be proven wrong on that topic.

Honestly this isn’t about me, or any surgeon for that matter. I’d be very content with the simple treatment of joint replacement, ACL reconstruction, and fracture treatment :P That would be an awesome life
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: .. on September 13, 2020, 04:35:03 PM

Quite the contrary, I’d love to see better, easier technology. I just question the feasibility behind it. Nature is still better than us... But I would love to be proven wrong on that topic.

Honestly this isn’t about me, or any surgeon for that matter. I’d be very content with the simple treatment of joint replacement, ACL reconstruction, and fracture treatment :P That would be an awesome life

So did you look at the patent that was showed to you: https://www.freepatentsonline.com/y2020/0223824.html?

First you said it's impossible.

Then you said it will hit the market in the future.

As for LSJL, you can read this: http://www.naturalheightgrowth.com/2020/08/29/new-lsjl-paper-update-revising-lsjl-method/

And we also have this: https://www.reddit.com/r/looksmaxxing/comments/hmj34y/what_future_heightmaxxing_regimen_may_look/
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: F_99 on September 13, 2020, 05:10:14 PM
Yep. I would personally hate it if my LLS profession got 'replaced' by this (or any other technology)
And we also have this: https://www.reddit.com/r/looksmaxxing/comments/hmj34y/what_future_heightmaxxing_regimen_may_look/
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: .. on September 13, 2020, 05:16:52 PM
For the record, Dr. Dror Paley was incredibly ignorant when asked about other possible methods and he would lie about the safety and consequences of LL.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Antoine on September 13, 2020, 05:35:27 PM
Hi Antoine,

Some peeptide manufacturers I think will be able to produce it, but I'm 100% sure they wont sell it to private individuals. In general, they work with pharmaceutical and biotechnology companies, colleges, universities, medical research institutions....

Maybe some manufacturers in India or China would sell to private individuals, but is it safe? That's a big question.

Hi Drop-Loud. I agree with you, that’s the big question. I’m not sure if this site sells peptides to individuals or not. We should investigate.
https://www.antibodies-online.com/peptide/938765/LPP+peptide/


The Korean compound seems promising to me. I guess it will be really useful for people with open growth plates. As for adults with fused growth plates, who knows? We could give it a try.
This is an example of the study behind the compound. It is written by the inventors and gives interesting information.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458850/

A complete overview of the compound patent can be found here.
https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2018194309
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: las vegas baby on September 13, 2020, 05:37:54 PM
.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Antoine on September 13, 2020, 06:01:04 PM
Well, the problem is feasibility of reopening growth plates. It sounds good on paper.

However closed growth plates are virtually indistinguishable from regular bone. Reopening growth plates is for now, an impossibility. I’d be highly surprised to see such a technology in the future. We do use for some medical conditions, medications that delay growth plate closures.


https://grantome.com/grant/NIH/R21-AR061265-02
In this project Ballock and Alsberg, an orthopedic surgeon and a professor respectively, stated that if we find a way to restore injured growth plates in children, then we could be able to regenerate growth plates in adults: “Successful regeneration of growth plate cartilage architecture in vivo would have a transformational impact on the practice of pediatric orthopaedic surgery, providing for the first time not only the ability to replace growth plates irreversibly damaged by trauma, infection or irradiation, but also the possibility of restoring longitudinal growth in individuals beyond the age of skeletal maturity.”
It was just an hypothesis, of course. Do you think that this hypothesis is far-fetched?
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: F_99 on September 13, 2020, 06:29:44 PM
For the record, Dr. Dror Paley was incredibly ignorant when asked about other possible methods and he would lie about the safety and consequences of LL.

Got any links/video?

__


This is an example of the study behind the compound. It is written by the inventors and gives interesting information.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458850/

So this is its tl;dr?

"A functionally improved indirubin derivative, KY19382, elongated tibial length through delayed senescence and further activation of the growth plate in adolescent mice. Collectively, our findings reveal an important role for CXXC5 as a suppressor of longitudinal bone growth involving growth plate activity."

Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Drop-Loud on September 13, 2020, 06:48:38 PM
Hi Antoine,

Thanks for sharing these links. We need to find a way to contact this Korean company to have more info about their drug.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: ghkid2019 on September 13, 2020, 07:08:33 PM
What even is the point of these compounds? We already fkin know how to elongate the growth plate. It's called human growth hormone. The only thing we give a shiet about is reopening growth plate. None of this shiet will do that, they are just an equivalent to hgh. They might even be better than hgh but again, WE DONT CARE, that's not the problem with gaining height as an adult with FUSED PLATES.

UNTIL We find something that opens growth plates again, all this shiet is borderline useless. We are not kids with growth plates, we are adults with ossified ephyphiseal lines already. It's goddamn bone...
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Drop-Loud on September 13, 2020, 07:57:52 PM
Great information here about growth plates : https://www.tapatalk.com/groups/lsjl/reopening-growth-plates-a-summary-t1033.html#p8141

Other links :
https://www.tapatalk.com/groups/lsjl/doctors-trip-t898.html

https://www.childrenscolorado.org/research-innovation/research-area/orthopedics-orthopedic-surgery/growth-plate-generation/

https://regenexx.com/blog/skeletal-stem-cells-found-living-in-the-growth-plates-may-one-day-make-us-taller/#gref
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Antoine on September 13, 2020, 11:46:18 PM
Hi Antoine,

Thanks for sharing these links. We need to find a way to contact this Korean company to have more info about their drug.

You’re welcome Drop-Loud. You’re right, we should find a way to contact them. I‘ll try. If I succeed, I’ll let you know.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Antoine on September 13, 2020, 11:58:08 PM
What even is the point of these compounds? We already fkin know how to elongate the growth plate. It's called human growth hormone. The only thing we give a shiet about is reopening growth plate. None of this shiet will do that, they are just an equivalent to hgh. They might even be better than hgh but again, WE DONT CARE, that's not the problem with gaining height as an adult with FUSED PLATES.

UNTIL We find something that opens growth plates again, all this shiet is borderline useless. We are not kids with growth plates, we are adults with ossified ephyphiseal lines already. It's goddamn bone...

I largely agree with you. However, there could be a very little chance that this compound works also for adults, maybe together with LPP. I don’t think so, but it never hurts to try. The patent of the Korean compound ambiguously says that the product is “prescribable to various age groups”.
Of course our priority should be giving back growth plates to adults.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Drop-Loud on September 14, 2020, 08:17:50 AM
Hi Antoine, thank you. I hope you will have more success than me. LPP and Indirubin are the most promising alternatives we have at the moment if it could work for adults.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Antoine on September 14, 2020, 10:05:59 AM
Hi Drop-Loud, you’re welcome. I agree with you. Let’s go ahead, we must not abandon hope.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: excited on September 14, 2020, 12:17:44 PM
You’re welcome Drop-Loud. You’re right, we should find a way to contact them. I‘ll try. If I succeed, I’ll let you know.

Hi Antoine!

Did u find any information about the korean company? if not maybe I can help :)
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Drop-Loud on September 14, 2020, 12:57:12 PM
Hi Excited,

This is the website of the Korean company, but they did not answered to my email. I completed the form 2 weeks ago.

Maybe Antoine and you will have more luck  :)

http://ckbiotech.co.kr/company/locationcontact/

Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Drop-Loud on September 14, 2020, 01:02:35 PM
That's what they plan to treat :

http://ckbiotech.co.kr/business-targets/patents/
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Antoine on September 14, 2020, 02:32:50 PM
@Drop-Loud & excited

Thank you. I’ll try to contact CKBiotech and let you know.
However, I read on their site these words about the compound: “The small molecule-induced activation of the Wnt/beta-catenin pathway enhances longitudinal bone growth around 10% by prolonged-activation of chondrocytes in the growth plates of the teen under going senescence.” This is note exactly encouraging, but we’ll see.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: F_99 on September 14, 2020, 02:57:18 PM
“The small molecule-induced activation of the Wnt/beta-catenin pathway enhances longitudinal bone growth around 10% by prolonged-activation of chondrocytes in the growth plates of the teen under going senescence.”

Doesn't senescence mean aging? So here it means fusing growthplates?
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Antoine on September 14, 2020, 03:04:41 PM
“The small molecule-induced activation of the Wnt/beta-catenin pathway enhances longitudinal bone growth around 10% by prolonged-activation of chondrocytes in the growth plates of the teen under going senescence.”

Doesn't senescence mean aging? So here it means fusing growthplates?


Yes. They claim the compound can delay the fusion of teens’ growth plates (i.e. growth plates that are gonna fuse soon), they don’t claim that the compound can reverse the fusion of growth plates after it’s happened.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: F_99 on September 14, 2020, 03:17:30 PM

Yes. They claim the compound can delay the fusion of teens’ growth plates (i.e. growth plates that are gonna fuse soon), they don’t claim that the compound can reverse the fusion of growth plates after it’s happened.

So it's useless for us.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Drop-Loud on September 14, 2020, 03:44:46 PM
If they respond to us, we will have a clear and definitive answer.

This is their patent : http://www.freepatentsonline.com/y2020/0223824.html

We should of course, focus on LPP too and growth plate regeneration or stem cells maybe.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: ghkid2019 on September 14, 2020, 03:50:25 PM
Great if we were fukin teens. WE ARENT.

And We know how to delay fusion. It's called fkin letrozole
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: cyborg4life on September 14, 2020, 03:59:55 PM
This is an interesting thread. Being a part-science nerd I'm always interested in the future of LL also and actually reached out to the the main guy of CK Biotech - Prof. Choi, a few weeks ago for a possible interview. He politely declined but he responded and unfortunately, this is what he said...

(https://imgur.com/Zesc9yP)


The search continues...
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: cyborg4life on September 14, 2020, 04:02:35 PM
[img=https://imgur.com/Zesc9yP][/img]
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: F_99 on September 14, 2020, 04:04:42 PM
This is an interesting thread. Being a part-science nerd I'm always interested in the future of LL also and actually reached out to the the main guy of CK Biotech - Prof. Choi, a few weeks ago for a possible interview. He politely declined but he responded and unfortunately, this is what he said...

(https://imgur.com/Zesc9yP)


The search continues...

Hey, nice videos btw.
Do you have anything else in mind (possible alternative methods)?

(The imgur link doesn't work)
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: cyborg4life on September 14, 2020, 04:11:27 PM
Oh really! Yeah you can tell how good I am at forum post links lol. Alright let's try this here is his email quote...

"Dear Victor,             
Thank you very much for your interest  with the CXXC5-Dvl PPI inhibitor story transferred.
We investigated the longitudinal bone growth especially enhancement of height of young people who undergo
 growth plate senescence.  The drug target  CXXC5, which interferes with its function  via PPI, only  increased during the period of growth plate senescence.
Blockade of CXXC5 function at the period, mice longitudinal bone growth   around 15-20% through activation of the Wnt/beta-catenin pathway involving bone  growth by regeneration.
Due to I am not a physician, I am not sure what I  will tell you in the interview.
If the information which  I provide is  enough, then, an interview openings for the public may not be necessary.
Best regards,
kang-yell"

Thanks yeah I have a few interesting ideas. I'm gonna try to see if I can make a video on that soon
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: F_99 on September 14, 2020, 04:12:46 PM
GJ contacting with them.

Thanks yeah I have a few interesting ideas. I'm gonna try to see if I can make a video on that soon

Excellent!
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Drop-Loud on September 14, 2020, 04:32:09 PM
Thanks a lot for sharing his response. Maybe we need to focus on Link protein N-terminal peptide (LPP), growth plates regeneration and stem cells.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: ghkid2019 on September 14, 2020, 04:49:59 PM
Thank you cyborg4life

And agreed with drop-loud ^, we need to prioritize reopen growth plate with stem cells or whatnot, without that no matter how much drugs we take to speed up growth plate growth, it'll be useless cuz we don't even have a growth plate to speed something up for
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Drop-Loud on September 14, 2020, 04:59:52 PM
Maybe Link protein N-terminal peptide (LPP) could work for people with closed growth plates. I'm sure that a drug will be available one day for people with closed growth plates. Unfortunately, researchers are not very interested in helping adults growing taller.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: F_99 on September 14, 2020, 06:05:35 PM
Maybe Link protein N-terminal peptide (LPP) could work for people with closed growth plates. I'm sure that a drug will be available one day for people with closed growth plates. Unfortunately, researchers are not very interested in helping adults growing taller.

From what I can understand here,
https://www.reddit.com/r/looksmaxxing/comments/icziqe/an_update/
(this is included in his post: https://www.hindawi.com/journals/sci/2018/3217895/)
he ditched out 'HDAC4 antagonists' for the safer LPP, but did he test it on rats or..?

Doesn't mention anything.


______



https://www.researchgate.net/publication/51368776_Histone_Deacetylase_4_Controls_Chondrocyte_Hypertrophy_During_Skeletogenesis
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Drop-Loud on September 17, 2020, 10:06:43 PM
I don't know. I asked the Reddit guy if he still think Indirubin could work for people with closed growth plates after the message written by Prof. Choi of CK Biotech. That's what he said :

Wnt/b-catenin still plays a role in the proliferation of collagen. What we're trying to do s basically treating the knee (few suggested the tibia) joints as a growth plates by controlling cartilage growth and ossification.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: ghkid2019 on September 17, 2020, 10:26:06 PM
So, basically, a no.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Strike_Poseidon on September 18, 2020, 03:10:26 PM
are you retarded man? This LPP method doesn't INVOLVE epiphyseal cartilage anymore, we are now working with joint cartilage and increasing the length of epiphysis (which can be unlimited but it would cause osteoarthritis if the cartilage isn't regenerated back again). Actually take the time to read instead of blabbing on like a little kid. LL surgeries involve increasing length in the middle of the bone, this involves increasing length through the ends of the bones.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: a on September 18, 2020, 03:19:12 PM
Can this shiet also happen to work on forearms and humeruses?
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: F_99 on September 18, 2020, 03:21:14 PM
Look who joined the forum ;D
Lmao
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: .. on September 18, 2020, 03:24:45 PM
are you retarded man? This LPP method doesn't INVOLVE epiphyseal cartilage anymore, we are now working with joint cartilage and increasing the length of epiphysis (which can be unlimited but it would cause osteoarthritis if the cartilage isn't regenerated back again). Actually take the time to read instead of blabbing on like a little kid. LL surgeries involve increasing length in the middle of the bone, this involves increasing length through the ends of the bones.

You can quote the poster you want to call 'retarded'.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Drop-Loud on September 18, 2020, 04:37:31 PM
The reddit guy also said this :

I think you'd get better luck with LPP if injected locally because there is so little that can enter cartilage after you become an adult. That's why disc disorders/diseases are so difficult to treat.

So according to him, LPP is the best solution so far.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Drop-Loud on September 18, 2020, 04:44:57 PM
Strike_Poseidon, It's a friendly group of people here; so please stay polite or leave this discussion!
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: ghkid2019 on September 18, 2020, 07:04:17 PM
Y u mad ooga booga
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: F_99 on September 19, 2020, 09:24:17 AM
Another interesting* post from him (new): https://www.reddit.com/r/Peptides/comments/ivcc43/post2017_information_on_already_known_peptides/

-PTD-DBM since this peptide is a CXXC5 inhibitor, it might help with longitudinal bone growth
https://www.life-science-alliance.org/content/lsa/2/2/e201800254.full.pdf

-IGF-2 for longitudinal bone growth
https://pubmed.ncbi.nlm.nih.gov/20499340/
https://pubmed.ncbi.nlm.nih.gov/25910049/

Quote
IGF-2 is one of the primary factors that helps children to grow, but as they grow older the body shifts in favor of IGF-1 over 2. Also IGF-2 activates BMP-9, which I don't think IGF-1 does.

There's still some IGF-2 in adults, but it's mostly for maintaining neural stem cell count, which helps with memory.

That's my understand of IGF-2 anyway.

And

Quote
Height Growth

_Syn-Coll, activates type 1 & 3 collagen through TGF-B upregulation. Not only does it boosts collagen synthesis, but decreases collage breakdown.
_ACE-031 improves bone density (only tested in elderly populations)
_BMPs (10mg is the limit)
_IGF1-LR3 & DES stimulates the proliferation and survival of various cell types including muscle, bone, and cartilage tissue. IGF-1 plays an important role in childhood growth and continues to have effects in adults.
_GHK-Cu (a grain of salt http //www.skinbiology.com/ghk-copper-peptide-stem-cell.html)
_Bonomarlot for bone marrow
_Bonothyrk for parathyroid? A peptide that elevates Parathyroid hormones, TGF-b regulates their production. Bonothyrk might be obsolete in place of Syn-Coll.
                                                                                     
                                                                                         ____________________________

*Possibly useful information; links might already have been posted.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Strike_Poseidon on September 19, 2020, 12:58:13 PM
Y u mad ooga booga
idk bro, maybe at the fact at that that people on this forum don't look at any other method apart from their LL surgery
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: ghkid2019 on September 19, 2020, 01:07:45 PM
idk bro, maybe at the fact at that that people on this forum don't look at any other method apart from their LL surgery

This is a limb lengthening surgery forum. Not a heightmax incel forum

Otra methods are certainly welcome but at it's core this forum is meant for the surgery. Not like any of these methods work anyways. No one has put anything that reopens growth plates. Yea they may work for kids but GH and AI also works and thats a real thing already no need for dreaming and cope like all dis posted RUSSIA RUSSIA COMPOUND KOREA COMPOUND THAT NO ONE HAS EVER TOUCHED

Maybe in future 20 years we will have some magic pill. But as of September 2020, the only way to grow as an adult is LL surgery,besides of course the 1 inch glucosamine spinal thingies temporary thingies.

Some ppl want their dysphoria alleviated realistically and not wait for a magic pill that does not exist yet
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Strike_Poseidon on September 19, 2020, 02:18:34 PM
yes, time to clean up this forum and show these hopeless people who will pay a surgeon 30 grand to break their legs, a way out
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: .. on September 19, 2020, 02:46:57 PM
yes, time to clean up this forum and show these hopeless people who will pay a surgeon 30 grand to break their legs, a way out

(https://lookism.net/gifs/slowclap.gif)
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: F_99 on September 19, 2020, 04:48:42 PM
This is a limb lengthening surgery forum. Not a heightmax incel forum

No. This is a Limb Lengthening forum. Which means it's about any way that can/possibly can lengthen your limbs (legs). Surgery is the way to go as of now, that's why most discussions here are about it.


Agree with the rest of your post.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Drop-Loud on September 19, 2020, 10:03:15 PM
Hi O_99,

Thanks a lot for sharing these links. I'm going to have a look at them now.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Body Builder on September 19, 2020, 10:30:22 PM
yes, time to clean up this forum and show these hopeless people who will pay a surgeon 30 grand to break their legs, a way out
Hopeless is someone who believes he will get taller with pills and bs like that.
Most of us are completely functional after LL and happy. You need to get out of a LIMB LENGTHENING forum if you think that there is another way to get taller, and create a forum about it.
You will gonna be 10 morond talking about pills, hormones, cloning, aliens and bs like that which are equally useless to becoming taller.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: ghkid2019 on September 19, 2020, 10:50:35 PM
yes, time to clean up this forum and show these hopeless people who will pay a surgeon 30 grand to break their legs, a way out

Ur on like 4-5 incel forums angry everyday starting arguments daily lol
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: .. on September 19, 2020, 11:04:11 PM
Hopeless is someone who believes he will get taller with pills and bs like that.
Most of us are completely functional after LL and happy. You need to get out of a LIMB LENGTHENING forum if you think that there is another way to get taller, and create a forum about it.
You will gonna be 10 morond talking about pills, hormones, cloning, aliens and bs like that which are equally useless to becoming taller.

Limb lengthening isn't necessarily distraction osteogenesis. This is technically still LIMB LENGTHENING:

http://www.youtube.com/watch?v=DcuNf4c5BF4
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Drop-Loud on September 19, 2020, 11:07:55 PM
Quote
No. This is a Limb Lengthening forum. Which means it's about any way that can/possibly can lengthen your limbs (legs). Surgery is the way to go as of now, that's why most discussions here are about it.


Agree with the rest of your post.

Well said
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: ghkid2019 on September 19, 2020, 11:17:34 PM
This sub topic is Limb Lengthening Surgery > Limb Lengthening Discussions.

Offtopic exists, suck each other's penises there maybe

Well said, thank you. Well said, thank you.

Whale said, hur hur hur reopen da ossified bone into da growth plate!!!1!1!1!1!!1!1!1!!1!1!1!1! So sxxyyy!!

Not a single person has posted a drug that specifically turns the ossified bone into cartilage. Not one.

But keep suckin each other's diks. Mentally masturbate with your fantasy drugs that are literally just more improved growth hormone without addressing the fact that ossified epiphyseal line has absolutely no cartilage cells or stem cells or anything, it's literally just bone. Keep fappin tho y'all doing great, convincing people there's actually a way to reopen growth plates as of right now haha
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Skyisthelimit on September 19, 2020, 11:22:19 PM
Limb lengthening isn't necessarily distraction osteogenesis. This is technically still LIMB LENGTHENING:

http://www.youtube.com/watch?v=DcuNf4c5BF4
THIS is garbage... and you’re incredibly naive if you believe this nonsense. I don’t understand what your end game is by sharing these type of videos.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Drop-Loud on September 19, 2020, 11:24:45 PM
The author of this reddit post : Post-2017 information on already known peptides said this

Question :
Quote
Intersting post.

So how we make adults, grow taller? Any news/tests on rats/rabbits?

A combination of LPP + IGF-2 injected into the knee for longitudinal bone growth?

Doesn't Insulin Growth Factor increase overgrowth of body tissues/cancer risk?


Answer

   
Quote
So how we make adults, grow taller?

In theory, yes.

    Doesn't Insulin Growth Factor increase overgrowth of body tissues/cancer risk?

Every growth factor has the potential to proliferate cells, including cancer cell if you have any, but Growth factors themselves don't cause cancer. Your body produces growth factors on a constant basis. IGF-1 in particular, is produce in your body by pulses hourly (assuming you're a healthy adult), so if IGF is so deadly, children wouldn't even be born alive, and most of r/peptides would drop like flies since most users used GH peptides in some form which converts into igf in the liver. If you don't have cancer already, you're only scaring yourself over igf-1, otherwise you should focus mainly on TA1 & PNC-27.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Body Builder on September 19, 2020, 11:30:02 PM
Limb lengthening isn't necessarily distraction osteogenesis. This is technically still LIMB LENGTHENING:

http://www.youtube.com/watch?v=DcuNf4c5BF4
We are talking about a surgery that works here, not about supernatural stupidities for the mentally retarded.
So no, technically limb lengthening is only distraction osteogenesis.
Everything else is a scam for the stupid ones.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: .. on September 20, 2020, 12:07:13 AM
Offtopic exists, suck each other's penises there maybe

Right, technically we should post non-surgery topics there and that would be perfectly appropriate.

But who cares?

This forum barely has any mods anyway lmao

THIS is garbage... and you’re incredibly naive if you believe this nonsense. I don’t understand what your end game is by sharing these type of videos.

Are you telling me that you don't accept Jesus as your savior, son?
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: ghkid2019 on September 20, 2020, 12:28:18 AM
Jesus christ will give me 3 inches after I inject Russian and Korean compound into my knee. Then I will get magical growth plate back out of thin air. Then I go to Allah and pray and journey to mecca then I will become 6 inch. Then I will become monk and inject igf-3 to make my growth plate turn from bone to cartilage. Then I pray to buddha and become Siddhartha. Then I go to Russia and do cross lengthening for 9 inch. I am now 6' 10 and about to prepare for my 5th Russian injection of BS-69-420 straight into the end of my femur. Then I will finally become tall enough so that girl like me. Then I will join incel forum and brag about how I have made it and invite Arabincel to my party
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Tartar on September 20, 2020, 12:30:47 AM
This topic sounds like an anti-vax group lol, sorry guys but you should think about the only and safest way to gain height actually, these other “thoughts” you are spreading are just fancy, there’s no way this can happens in less than many dozens of years, you are just concerned about limb lengthening but there are many many applications of the tissues regeneration people and researchers are interested, for example cartilage (for which there is still a huge improvement about artificial protheses for several joints) and for all of these applications there’s no answer. Assuming that’s impossible to bring back your whole body to a stem cell state, how can you even think that try to stimulate a bone growth can be done without any surgery and how can you even think that this could be safer or even just cheaper than all the ways actually available that just use your natural osteogenesis to fill a gap surgically created.  Bone is one of the few tissues is possible to regenerate totally with the same tissue present before, this is one of safest and more natural way to grow you have to realize this
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Tartar on September 20, 2020, 12:34:46 AM
We talk about grow plates closed but it’s not something you can open again like a door how can you even hope that there’s the answer to gain cms and some incels behind a Pc are studying about it without any recognition by the scientific community, or maybe that some villains are trying to hide the truth to make more money. Cmon guys grow up (mentally)
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: .. on September 20, 2020, 12:40:29 AM
This topic sounds like an anti-vax group lol, sorry guys but you should think about the only and safest way to gain height actually, these other “thoughts” you are spreading are just fancy, there’s no way this can happens in less than many dozens of years, you are just concerned about limb lengthening but there are many many applications of the tissues regeneration people and researchers are interested, for example cartilage (for which there is still a huge improvement about artificial protheses for several joints) and for all of these applications there’s no answer. Assuming that’s impossible to bring back your whole body to a stem cell state, how can you even think that try to stimulate a bone growth can be done without any surgery and how can you even think that this could be safer or even just cheaper than all the ways actually available that just use your natural osteogenesis to fill a gap surgically created.  Bone is one of the few tissues is possible to regenerate totally with the same tissue present before, this is one of safest and more natural way to grow you have to realize this

Sorry man, but you know we can't really trust the opinions of people who have done LL about potential LL alternatives, right?
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: ghkid2019 on September 20, 2020, 12:43:06 AM
We talk about grow plates closed but it’s not something you can open again like a door how can you even hope that there’s the answer to gain cms and some incels behind a Pc are studying about it without any recognition by the scientific community, or maybe that some villains are trying to hide the truth to make more money. Cmon guys grow up (mentally)

Perfectly said bro. They gonna attack you in about 5 minutes so leave while u can tho. Ur 100% right. These fkin retards think fused growth plates is still cartilage like it used to be.. no dumbassses it's fking ossified bone it's functionally no different than the entirety of the rest of your femur and any hard bone from a 40 year old...

Run tho arab incel is aboutta come and call u names haha
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: ghkid2019 on September 20, 2020, 12:45:36 AM
I'll say it again, the best thing we will have after stryde in the next 10-20 years is a stem cell/cartilage graft/implant, and that still requires a fracture into the bone to install it so you will still be breaking ur bones daddy

Keep believing magic injection can turn an arbitrary line in your femur into cartilage tho. It make u feel better and mental masturbation, keep doing it arab incels
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Body Builder on September 20, 2020, 08:11:39 AM
Sorry man, but you know we can't really trust the opinions of people who have done LL about potential LL alternatives, right?
For sure we can't trust people who believe in miracles and magic pills to get taller compared to veterans who did what they have to to get taller.

I am starting to think that you are mentally unstable because you are really frustrated about your height (we had almost the same height so I truly understand you) but at the same time you are too scared to do LL and you keep believing bs hoping that one day you'll get taller by a miracle or a pill or an injection or something easy like that.
In reality, you'll stay in misery for your whole life because there won't be an alternative until you get so old to not even care about height but to just stay alive.

Wake up dude, LL nowadays is safer than ever. Its a pity to be in a so messed up situation due to being in a height that you hate, without doing something real about that.
I hope one day you'll understand before its too late.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: F_99 on September 20, 2020, 09:01:22 AM
Hi O_99,

Thanks a lot for sharing these links. I'm going to have a look at them now.

Yo, np.
I actually asked him a question, but you posted it already above. He mentioned rapamycin before, so I wonder if he knows anything about the c60 fullerene, because it belongs to the 'anti-senesence' field too.

Quote
Have you ever experimented with this fullerene (c60)?

https://onlinelibrary.wiley.com/doi/full/10.1002/art.22917
(http://www.limblengtheningforum.com/index.php?topic=65449.0)

I'm wondering if it can not only prevent cartilage degenaration but also ''reverse'' it, causing articular cartilage regenaration/regrowth hence resulting in greater total leg length, but couldn't find anything


This sub topic is Limb Lengthening Surgery > Limb Lengthening Discussions

Offtopic exists, suck each other's penises there maybe

That's not what you said originally.
This topic is about the future of limb lenghtening + what do you hope to see happen, not strictly about the future of the surgery, so you can ask the original poster why they put it in the LLS sub-board.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: ghkid2019 on September 20, 2020, 09:20:24 AM
Brondo!!! Why u do this??? Man u is no goodie!! Goddamit brondo why daddy you mis post wrong area sir!!! I can't beliebe dis. Am in shambels rn. Me depreshun now fuk man I hate dis!!!1!!1! Brondo why u betray me Mr. Siddhartha?
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Antoine on September 20, 2020, 06:43:57 PM
Joking aside, if we have to think about the future of limb lengthening, I’d say that Dr. Michael J. Assayag MD’s take shows adherence to reality but also the lack of effort to try out new things and to cooperate with other doctors and researchers in order to make cosmetic limb lengthening a really comfortable and bearable surgery. This lack of effort is the biggest issue of cll.
So, I hope that both of these scenarios will come true.
1)Completely revised limb lengthening surgery: laser osteotomy (https://aot.swiss/en/carlo/), distraction performed in a non-invasive/minimally invasive way by nanobots or something like that (no nails, no metal implants, no Ilizarov apparatus), stem cells that allow bones, tendons and muscles to stretch and regenerate easily, safely and quickly.
2)Creation and implantation of artificial growth plates that allow long bones to grow longitudinally again, as during puberty. Many research projects came very neat to this, as links below show. If this kind of research had been heavily funded, we could have had artificial growth plates implanted in our bones yet.

https://www.researchgate.net/publication/298275420_Construction_of_artificial_epiphyseal_plate_using_epiphyseal_plate_chondrocytes_of_rabbits_and_combined_scaffold
https://www.physoc.org/abstracts/enlargement-of-growth-plate-chondrocytes-in-agarose-culture/
https://www.unmc.edu/news.cfm?match=20659
https://www.semanticscholar.org/paper/Growth-Plate-Regeneration-Using-Polymer-Based-Clark/75a843c9d4887d883d4ca7b75208b18dabb02a33
https://www.eurekalert.org/pub_releases/2020-05/tifb-csa051920.php
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Drop-Loud on September 20, 2020, 11:12:17 PM
Hi O_99,

Good Idea to ask him about fullerene (c60). Maybe he will have more scientific info about it. I think we could give it a try as it is safe and easy to find.

Hi Antoine,

I think most LL surgerons don't want to loose time, effort and money to find new solutions. They make enough money with actual technology. I think all people across the globe looking to increase their height with newer techniques should unit themselves to fund research.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Drop-Loud on September 21, 2020, 03:43:39 AM
Another great post about growth plates

https://www.tapatalk.com/groups/lsjl/the-most-important-topic-in-growth-plate-reopening-t1029.html
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: F_99 on September 21, 2020, 09:06:54 AM
Nanobots to perform distraction osteogenesis are decades away at best; Unfortunately, wishful thinking.

Hi O_99,

Good Idea to ask him about fullerene (c60). Maybe he will have more scientific info about it. I think we could give it a try as it is safe and easy to find.

Hey, yes.
He's still confident about the LPP thing (in theory), inject it locally (knee) because there is so little that can enter cartilage after you become an adult.
We need test results though.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: .. on September 21, 2020, 01:01:03 PM
For sure we can't trust people who believe in miracles and magic pills to get taller compared to veterans who did what they have to to get taller.

I am starting to think that you are mentally unstable because you are really frustrated about your height (we had almost the same height so I truly understand you) but at the same time you are too scared to do LL and you keep believing bs hoping that one day you'll get taller by a miracle or a pill or an injection or something easy like that.
In reality, you'll stay in misery for your whole life because there won't be an alternative until you get so old to not even care about height but to just stay alive.

Wake up dude, LL nowadays is safer than ever. Its a pity to be in a so messed up situation due to being in a height that you hate, without doing something real about that.
I hope one day you'll understand before its too late.

Look mate, if you have some problem with me then just insult me straight up instead of being passive-aggressive about it and indirectly alluding to me using idiotic beat-around-the-bush terminology like this. It's laughable to call someone a coward when you do this.

I honestly don't give a sh*t about Stryde. Is it an improvement to the distraction osteogenesis technique? Sure. But it doesn't solve my (and many other people's) problems with distraction osteogenesis, which is the permanent loss of athletic ability and the risk of permanent complications. Both those problems still exist and you stand a very real chance of facing them whether you go to Dr. Paley or "Sarin the butcher" as you like to call him.

It's not a matter of pain or death. I'm not the least bit afraid of either. If these were the only "risks" implicated in CLL, I would be first in line to get it done. I need my athletic ability and cannot afford to have it hampered, which is why CLL is not an acceptable proposition for me. Plenty of others are in the same boat. Still others are not okay with risking ending up like one of the several posters (such as unicorn) whose lives were ruined by distraction osteogenesis.

Despite the fact that I regularly speak about attraction and its ramifications on this board, I'm not interested in getting taller so I can attract women. I'm not interested in sxx or relationships and haven't been for a long time. Getting taller is purely about overcoming my PHYSICAL (and to a lesser extent, social and workplace) limitations, not about peacking.

You look like a luddite imbecile when you spout garbage about "miracles" and "fairy tales" regarding novel technologies. If you don't understand the science, why criticize it? Especially when the relevant technology ALREADY EXISTS (induced Pluripotent Stem Cells) and the principal part of the procedure (generation and implantation of artificial epiphyseal cartilage) has ALREADY BEEN DONE and successfully shown to work in animal models.

If your problems with your height were purely about attracting women then sure, CLL can fix it for you. Get it done and move on. Back to your squat rack to cope with your bullsh*t weights.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Body Builder on September 21, 2020, 02:16:38 PM

A weirdo who didn't know why he even wanted to become taller and had absolutely no will to get taller.
I am sure he still moans and looks for magic pills like you while living in misery.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: F_99 on September 21, 2020, 02:28:10 PM
A weirdo who didn't know why he even wanted to become taller and had absolutely no will to get taller.

"..But I'm a creep, I'm a weirdo.
 What the hell I'm doing here?
 I don't belong here.."
https://www.youtube.com/watch?v=uo92iIPOYY4
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: F_99 on September 24, 2020, 06:07:55 PM
From another interesting* post link from him he shared (new): **

*Possibly useful information; links might already have been posted.

** (new one): https://www.reddit.com/r/Peptides/comments/iyjn9o/a_general_list_of_peptides_plus_peptides_you/


1. -Self-improvement;Antarctic krill peptides (AKP) 
https://www.eurekaselect.com/182760/article (but on young mice; 3wks/old)

->AKPs significantly increased the longitudinal bone growth and improved bone strength. In addition, AKPs remarkably promoted proliferation and hypertrophy of chondrocytes in the growth plate.


2. -Self-improvement;ASB20123
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386482/ (on 8wks/old rats; rats stop growing at 7-8mnths/old)
https://pubmed.ncbi.nlm.nih.gov/31509532/ (12 mnths/old rats; not sure why it says with a little epiphyseal plate)

->It potently stimulated skeletal growth in rats in a dose-dependent manner, and sc infusion was more effective than bolus injection at the same dose.


3. 8-Nitro-cGMP promotes bone growth through expansion of growth plate cartilage
https://www.sciencedirect.com/science/article/abs/pii/S0891584917305956?via%3Dihub


4. A newly discovered stem cell that keeps bones growing
https://www.nature.com/articles/d41586-019-00527-w?utm_source=fbk_nnc&utm_medium=social&utm_campaign=naturenews&sf209700336=1


5. -Cosmetic, Healing;NHGFVVEVTNHGFVVEVT 
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457080/ (bone renegeration; not sure about this one)
is one of the few selected as osteogenic-enhancing peptides with both the ability for osteogenic cell-selective proliferation and osteogenic differentiation. These results indicate that osteogenic-enhancing peptides are derived from BMP sequences according to the original peptide array method developed in the present study.


6. -Hormonal;PTH
https://link.springer.com/article/10.1007/s007740200011 (Human PTH (1–34) induces longitudinal bone growth in rats; relatively old)

->A stimulatory role for PTH 1-34 on tendon-to-bone healing was first suggested by Rodeo et al. who reported increased bone and fibrocartilage formation after recombinant parathyroid hormone (rhPTH) treatment in a rat rotator cuff model. Additionally, we found that there was a significant increase in the mineralization of the subchondral bone, as determined by alizarin complexone labeling, in the I-PTH group.


7. -Self-improvement;Link protein N-terminal peptide (LPP or Link N)
https://www.sciencedirect.com/science/article/abs/pii/S0003986100917582
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831317/ (1)
https://febs.onlinelibrary.wiley.com/doi/full/10.1111/j.1432-1033.1993.tb17636.x (old) (2)

->Stimulated the proliferation of Cartilage Stem/Progenitor Cells (CSPC) and accelerated the site-directional migration. Higher expression of SOX9, collagen II, and aggrecan were demonstrated in CSPCs treated with LPP. Data suggest that LPP may be a useful therapeutic substitute for direct BMP administration to treat IVD degeneration and to ameliorate IVD-associated chronic low back pain.
It's proposed that this peptide, along with several other compounds, might increase adult height.

(1) Conclusion. LPP showed application prospect in cartilage regeneration medicine by stimulating proliferation, migration, and chondrogenic differentiation of cartilage stem/progenitor cells.

(2) Since a proportion of the link protein extracted from human and pig cartilage has already undergone proteolysis to remove peptides from its N‐terminal region, these peptides may be produced in articular cartilage during the normal process of turnover and ageing.

+
-PTD-DBM since this peptide is a CXXC5 inhibitor, it might help with longitudinal bone growth
https://www.life-science-alliance.org/content/lsa/2/2/e201800254.full.pdf

-IGF-2 for longitudinal bone growth
https://pubmed.ncbi.nlm.nih.gov/20499340/
https://pubmed.ncbi.nlm.nih.gov/25910049/
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Drop-Loud on September 25, 2020, 10:23:54 PM
Hi O_99,

Thank you so much for sharing all this links. It's very promising. Great job!
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: ghkid2019 on September 25, 2020, 10:58:59 PM
Literally only 4 is relevant lol. Fück is this shīt we don't need another form of hgh
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Drop-Loud on September 26, 2020, 02:41:41 AM
The most interesting finding would be these ones for people who want to grow taller. Maybe some specialists could confirm :


4. A newly discovered stem cell that keeps bones growing
https://www.nature.com/articles/d41586-019-00527-w?utm_source=fbk_nnc&utm_medium=social&utm_campaign=naturenews&sf209700336=1


7. -Self-improvement;Link protein N-terminal peptide (LPP or Link N)
https://www.sciencedirect.com/science/article/abs/pii/S0003986100917582
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831317/ (1)
https://febs.onlinelibrary.wiley.com/doi/full/10.1111/j.1432-1033.1993.tb17636.x (old) (2)

->Stimulated the proliferation of Cartilage Stem/Progenitor Cells (CSPC) and accelerated the site-directional migration. Higher expression of SOX9, collagen II, and aggrecan were demonstrated in CSPCs treated with LPP. Data suggest that LPP may be a useful therapeutic substitute for direct BMP administration to treat IVD degeneration and to ameliorate IVD-associated chronic low back pain.
It's proposed that this peptide, along with several other compounds, might increase adult height.

(1) Conclusion. LPP showed application prospect in cartilage regeneration medicine by stimulating proliferation, migration, and chondrogenic differentiation of cartilage stem/progenitor cells.

(2) Since a proportion of the link protein extracted from human and pig cartilage has already undergone proteolysis to remove peptides from its N‐terminal region, these peptides may be produced in articular cartilage during the normal process of turnover and ageing.


antarctic krill akp seems to work like indirubin if I'm right?
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: F_99 on September 26, 2020, 07:04:01 PM
Literally only 4 is relevant lol. Fück is this shīt we don't need another form of hgh

For the adults whom had their growth plates closed we need to proliferate not only their existing chondrocytes , but also their dormant chondrocyte stem cells which LPP (Link protein N-terminal peptide) holds a lot of promise to achieve. LPP has been tested on vitro/vivo (https://www.hindawi.com/journals/sci/2018/3217895/
https://onlinelibrary.wiley.com/doi/abs/10.1002/1529-0131(199801)41:1%3C157::AID-ART19%3E3.0.CO;2-J)
and human type II collagen cells (https://onlinelibrary.wiley.com/doi/abs/10.1002/1529-0131(199801)41:1%3C157::AID-ART19%3E3.0.CO;2-J) with positive results.

Hi O_99,

Thank you so much for sharing all this links. It's very promising. Great job!

Hey, by the way what's up with this? https://www.tapatalk.com/groups/lsjl/viewtopic.php?p=8384#p8384
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: ghkid2019 on September 26, 2020, 07:43:32 PM
Kill this topic alrdy lol. Keep believing your ossified growth plate area still contains anything but bone. "Dormant chondrocytes" lul
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: F_99 on September 26, 2020, 07:46:25 PM
Kill this topic alrdy lol. Keep believing your ossified growth plate area still contains anything but bone. "Dormant chondrocytes" lul

I'd rather take into consideration what biohackers think could be possible for height increase on adults than an internet kid's opinion.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: ghkid2019 on September 26, 2020, 07:52:06 PM
Your so called biohacker doesn't even know what lyophilized powder or refrigeration is and thus rejects HGH and used 30 different peptides that does the same shiet because "muh HGH no stable"
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: F_99 on September 26, 2020, 07:56:10 PM
Your so called biohacker doesn't even know what lyophilized powder or refrigeration is and thus rejects HGH and used 30 different peptides that does the same shiet because "muh HGH no stable"

Who cares? You're calling hypothetical solutions irrelavant without even reading into them.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: ghkid2019 on September 26, 2020, 08:07:30 PM
Ye mb. Just wanna see more growth plate regeneration things, rather than just stuff that works in existing growth plate. Who knows hopefully we will get stem cell injection and work from there
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Drop-Loud on September 26, 2020, 09:16:18 PM
Quote
Hey, by the way what's up with this? https://www.tapatalk.com/groups/lsjl/viewtopic.php?p=8384#p8384

Hi O_99,

It's similare to this I think : https://www.youtube.com/watch?v=Vagcl675dms

https://www.mirror.co.uk/news/uk-news/could-height-enhancing-a-grow-bics-workout-really-1332212

Some people who tried it say it works, some don't. You need to live in the UK to be able to beneficiate from it.

Otherwise, I don't know much about this "Height Increase Project 2020 Telegram Group" and I don't know how they are organized. I will try to know more.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: F_99 on September 26, 2020, 09:21:53 PM
Yeah, I was talking about the stretching for hours thing. That Ukrainian guy mentioned used to do something similar. Scam/spine temporary height increase looks like.   >:(
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Drop-Loud on September 26, 2020, 09:23:51 PM
An other interesting post about creating artificial growth plates : https://www.tapatalk.com/groups/lsjl/viewtopic.php?p=8456#p8456
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Drop-Loud on September 26, 2020, 09:28:19 PM
Quote
Yeah, I was talking about the stretching for hours thing. That Ukrainian guy mentioned used to do something similar. Scam/spine temporary height increase looks like.   

I'm a bit skeptical about stretching. You will gain temporary height I think and not very much.

Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: .. on September 26, 2020, 10:51:20 PM
Hi O_99,

It's similare to this I think : https://www.youtube.com/watch?v=Vagcl675dms

https://www.mirror.co.uk/news/uk-news/could-height-enhancing-a-grow-bics-workout-really-1332212

Some people who tried it say it works, some don't. You need to live in the UK to be able to beneficiate from it.

A-Grow-Bics no longer uses The Stretch Rack. They claim that inversion is far more effective.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: F_99 on September 27, 2020, 10:30:10 AM
Thanks yeah I have a few interesting ideas. I'm gonna try to see if I can make a video on that soon

So you did make a video. Nice.
https://www.youtube.com/watch?v=QOKxPRt6qTE

First time I hear about this: LIPUS technology (which is low-intensity pulsed ultrasound) and how it could stimulate bone growth as some studies have been noted in jaw bones of rats.
Interesting.

Also the company BGRI reached out to you and wrote a guest article? (Part II of this blog post)
https://cyborg4life.com/future-alternatives-to-limb-lengthening-surgery/

The guy who's also commeting at the end (Harald Oberlaender) funded "Biomedical Growth Research Initiative" (BGRI):
http://www.limblengtheningforum.com/index.php?topic=5139.0

He's still on this forum, last time active, yesterday http://www.limblengtheningforum.com/index.php?action=profile;u=5003
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Drop-Loud on September 29, 2020, 02:36:03 AM
Very Interesting post, thanks for sharing.

The only between rats and us is that their growth plates never close. I don't know if it's the same for rabbits.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Drop-Loud on October 03, 2020, 01:07:59 AM
For those interested, Dr. Dror Paley is the First Surgeon in the World to Perform a New Limb Lengthening Procedure with the PRECICE™ Plate Implant at St. Marys Medical Center & the Palm Beach Childrens Hospital

https://www.palmbeachchildrenshospital.com/news/newsroom/dr-dror-paley-is-the-first-surgeon-in-the-world-to-perform-a-new-limb-lengthening-procedure-with-the-precice-plate-implant-at-st-marys-medical-center-the-palm-beach-childrens-hospital

https://www.youtube.com/watch?v=fn3yuoPd2FE
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: ghkid2019 on October 03, 2020, 02:09:03 AM
It is very good for children, no more long time in external fixator needed for leg length discrepancy and can fix it without shoving a rod in to disturb growth plate.

The best thing is the no more external needed for kids. A kid doesn't have to deal with all that scary stuff.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Drop-Loud on October 03, 2020, 10:49:33 PM

IGF2 is very likely able to form new growth plates

https://www.naturalheightgrowth.com/2013/11/19/igf2/

https://www.tapatalk.com/groups/lsjl/continue-investigation-t1006.html#p7491

https://www.tapatalk.com/groups/lsjl/growth-taller-investigation-t1004.html#p7466



 Load-Driven Bone Lengthening

https://grantome.com/grant/NIH/R03-AR055322-01A1

https://projectreporter.nih.gov/project_info_description.cfm?aid=7670257


Patent application title: Bone Growth Compositions and Methods

http://www.patentsencyclopedia.com/app/20120276204

http://www.patentsencyclopedia.com/app/20120004726#b

http://www.heightquest.com/2012/02/does-bone-mineral-density-affect-height.html

http://www.naturalheightgrowth.com/2013/10/31/bmpr1a-may-key-form-new-growth-plates/

http://www.naturalheightgrowth.com/wp-content/uploads/2012/12/ElbowLoading.pdf

http://www.naturalheightgrowth.com/2012/11/19/10-scientific-papers-on-the-human-growth-process-and-mechanics-the-reader-should-definitely-read/


Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: F_99 on October 18, 2020, 09:49:10 AM
The only between rats and us is that their growth plates never close. I don't know if it's the same for rabbits.

Yes. He mentioned we should use rabbits because their growth plates close due to sxx hormones (unlike rats) similarly to human's.

Also I asked him if this:
3. 8-Nitro-cGMP promotes bone growth through expansion of growth plate cartilage
https://www.sciencedirect.com/science/article/abs/pii/S0891584917305956?via%3Dihub
could help adults grow taller; and he said "yes, but you would likely get more results from those who have open growth plates with 9NCamp".

If you find out more about it, let me know.

Also, this guy is doing the Kojima method? https://www.tapatalk.com/groups/lsjl/my-shinbones-routine-based-on-kojima-and-skyheight-t1051.html

And Tyler is still going http://www.limblengtheningforum.com/index.php?topic=65630.0
but we need X-ray results. https://www.tapatalk.com/groups/lsjl/modified-lsjl-update-method-t1032-s110.html
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: 184dream on October 24, 2020, 10:39:45 AM
I made a tobic previously dr karyne payne uni of colorado had already succeeded to make a growth plate and they made it customized by 3d printing
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: 184dream on October 24, 2020, 10:45:11 AM
This post is just great
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Bjoern77 on April 19, 2021, 11:35:07 PM
Whatever it's gonna be: this Trooper is going to inject every   that promises miraculous results ;D 8)
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: TheDream on April 20, 2021, 02:40:58 AM
For those interested, Dr. Dror Paley is the First Surgeon in the World to Perform a New Limb Lengthening Procedure with the PRECICE™ Plate Implant at St. Marys Medical Center & the Palm Beach Childrens Hospital

https://www.palmbeachchildrenshospital.com/news/newsroom/dr-dror-paley-is-the-first-surgeon-in-the-world-to-perform-a-new-limb-lengthening-procedure-with-the-precice-plate-implant-at-st-marys-medical-center-the-palm-beach-childrens-hospital

This is pretty interesting. Does this mean the metal rods can be completely avoided in the LL procedure? Could it be used for adult LL patients too? If we can avoid rods and minimize nails it could potentially mean a better way of lengthening tibias internally. You probably can't walk until after the lengthening but if combined with better lengthening steps etc. it could really improve internal tibia lengthening I'd assume.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Bjoern77 on September 12, 2021, 02:29:12 PM
There were 60 years from external Ilizarovs to a full weight bearing magnrtic internal nail.
If you think that in less than 30 years there will be a non invasive alternative to get taller then wait for it.
You will just become an old man waiting for nothing.

Personally I am not delusional and know that there wont be a non invasive akternative at least till I get old.
You can't wait by leting your life pass as being short for a delusion, not my problem.
+1
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Bjoern77 on September 12, 2021, 02:29:57 PM
c60 could be a good way to start. It should be safe and easy to find. + it's anti aging.
It can give you cancer if exposed to light, afair?
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: SpeedDialer on September 13, 2021, 04:48:26 PM
Is Gnail the future/anything good about it? Or once the next precise/stryde model comes out it is finished?

Ex: any reason clicking is better than magnetic?
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Bjoern77 on September 13, 2021, 09:47:46 PM
Got any links/video?

__


So this is its tl;dr?

"A functionally improved indirubin derivative, KY19382, elongated tibial length through delayed senescence and further activation of the growth plate in adolescent mice. Collectively, our findings reveal an important role for CXXC5 as a suppressor of longitudinal bone growth involving growth plate activity."

wait... KY19382... isn't that the upcoming hair loss treatment via WNT pathway modulation or something?  ???
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Bjoern77 on September 13, 2021, 10:22:16 PM
Hi Antoine, thank you. I hope you will have more success than me. LPP and Indirubin are the most promising alternatives we have at the moment if it could work for adults.
What makes them special?
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Body Builder on September 13, 2021, 11:25:33 PM
Is Gnail the future/anything good about it? Or once the next precise/stryde model comes out it is finished?

Ex: any reason clicking is better than magnetic?
Absolutely no. Gnail or any other mechanican nails have only disadvantages compared to a fully weight bearing magnetic nail like stryde.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: SpeedDialer on September 13, 2021, 11:46:39 PM
We are sort of in this odd situation where there is data against the Stryde nail. So G-nail is the next best weight bearing option. There is no data against the G-nail that is getting it recalled but I wonder

Or is G-nail so similar to Albizzia that we don't need to worry/it is safe?
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: ilovescience on September 14, 2021, 04:33:42 AM
I think the future of LL would be safer and easier. Probably no surgery needed.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: MakeMeTallAF on September 14, 2021, 05:56:18 AM
That's not happening anytime soon. The only way that's possible is if we find a way to un-fuse growth plates, which will be difficult since after they fuse they are pretty much indistinguishable from the rest of the bone.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Exxon on September 14, 2021, 06:10:46 AM
I think the future of LL would be safer and easier. Probably no surgery needed.

I reckon stem cells oriented. The problem is funding, and no centralized support.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: ilovescience on September 14, 2021, 06:10:56 AM
That's not happening anytime soon. The only way that's possible is if we find a way to un-fuse growth plates, which will be difficult since after they fuse they are pretty much indistinguishable from the rest of the bone.

If they finally find a way to unfuse growth plates, everyone could choose it for cosmetic surgery, and everyone can still grow taller even in their adulthood. Hopefully there won't be heightism in the future, and everyone could compete fairly. That dream may come true this century, any hope?
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Exxon on September 14, 2021, 06:15:03 AM
If they finally find a way to unfuse growth plates, everyone could choose it for cosmetic surgery, and everyone can still grow taller even in their adulthood. Hopefully there won't be heightism in the future, and everyone could compete fairly. That dream may come true this century, any hope?

It's definitely possible and maybe we can do it but we have to combat two things:

1. Research Money
2. Existing surgeons that undergo CLL

1 is pretty self explanatory, if you want to make significant advancements into science you're going to have to fund it greatly. We sadly do not have a big enough community to fund a great project like this. 2 is that people like Paley or any other experienced CLL surgeon will not want non-surgery alternatives which results to permanent height gain to occur, they will lose money and they'll do anything to not let information like this to go out to the public.

Those two things are holding us back from advancement.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: ilovescience on September 14, 2021, 06:17:36 AM
I reckon stem cells oriented. The problem is funding, and no centralized support.

We need grow taller advocates so medias will understand, and funding should be no problem. Stem cell plays a big role in healing after LL. Have you heard of PRP treatment which is being done in many clinics? That's how they should approach in order to use stem cell to heal after LL.
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Bjoern77 on September 16, 2021, 09:16:29 PM
Maybe Link protein N-terminal peptide (LPP) could work for people with closed growth plates. I'm sure that a drug will be available one day for people with closed growth plates. Unfortunately, researchers are not very interested in helping adults growing taller.

So what is that LPP in layman's terms?
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Bjoern77 on September 16, 2021, 09:52:02 PM
Jesus christ will give me 3 inches after I inject Russian and Korean compound into my knee. Then I will get magical growth plate back out of thin air. Then I go to Allah and pray and journey to mecca then I will become 6 inch. Then I will become monk and inject igf-3 to make my growth plate turn from bone to cartilage. Then I pray to buddha and become Siddhartha. Then I go to Russia and do cross lengthening for 9 inch. I am now 6' 10 and about to prepare for my 5th Russian injection of BS-69-420 straight into the end of my femur. Then I will finally become tall enough so that girl like me. Then I will join incel forum and brag about how I have made it and invite Arabincel to my party

Angela Merkel approves!
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Bjoern77 on September 17, 2021, 09:25:32 PM
1)Completely revised limb lengthening surgery: laser osteotomy (https://aot.swiss/en/carlo/), distraction performed in a non-invasive/minimally invasive way by nanobots or something like that

You watched too much Star Trek  ;D
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Christopherbulder on September 17, 2021, 10:59:49 PM
I am an albizzia alumnus
albizzia remains a relatively safe nail and weight carrier the only problem remains the clik rather painful at the start then it goes alone
Title: Re: What is the future of limb lengthening? What do you hope to see happen?
Post by: Bjoern77 on September 18, 2021, 02:24:43 PM
Otherwise, I don't know much about this "Height Increase Project 2020 Telegram Group" and I don't know how they are organized. I will try to know more.
How do I get into this autism group?