It's rather dangerous to use large amounts of growth hormone after your growth plates have fused. The side effects and negative possibilities far outweigh 1 inch IMO.
At least with LL it's guaranteed height for the most part even though the risks are very real.
There's a possibility with the large amounts of growth hormone that you could simply fk yourself up. Ear/nose growth etc.
No, they really don't. The only "side effects" you'd encounter as a result of dosing even 10 I.U. of pharmaceutical grade rHGH for 6 months - 1 year would be mild joint paint/carpal tunnel syndrome, substantial bloating/edema (water retention), and mild to moderate hypoglycemia.
All the warnings about "cancer", "acromegaly", or whatever other boogeymen are nothing but scaremongering by the pharmaceutical industry so that aging people (30+) won't start demanding rHGH replacement therapy (right now it's marketed as """cosmetic""" anti-aging) once they find out all of its benefits and how fast a person starts losing their natural HGH production after their teen years. To debunk this nonsense:
[b
]1. "Cancer!!!"[/b]
rHGH at ANY dose doesn't "increase cancer risk", at least not the way people think it does. The metabolite of HGH, Insulin-like Growth Factor 1 (IGF-1), is a cell proliferator, which means it causes cells to divide. Anything that increases the rate of cell division is technically doing the same thing as cancer does.
However, that doesn't mean HGH or IGF-1 "causes" cancer, which happens when a defective cell fails to self-terminate (through a process called "apoptosis") and begins to divide uncontrollably instead.It does create a cellular environment that is conducive to cell survival (including defective cells), which would indirectly raise your relative risk of developing cancer, in theory. However:
https://www.ncbi.nlm.nih.gov/pubmed/16430706Abstract
The ability of GH, via its mediator peptide IGF-1, to influence regulation of cellular growth has been the focus of much interest in recent years. In this review, we will explore the association between GH and cancer. Available experimental data support the suggestion that GH/IGF-1 status may influence neoplastic tissue growth. Extensive epidemiological data exist that also support a link between GH/IGF-1 status and cancer risk. Epidemiological studies of patients with acromegaly indicate an increased risk of colorectal cancer, although risk of other cancers is unproven, and a long-term follow-up study of children deficient in GH treated with pituitary-derived GH has indicated an increased risk of colorectal cancer. Conversely, extensive studies of the outcome of GH replacement in childhood cancer survivors show no evidence of an excess of de novo cancers, and more recent surveillance of children and adults treated with GH has revealed no increase in observed cancer risk. However, given the experimental evidence that indicates GH/IGF-1 provides an anti-apoptotic environment that may favour survival of genetically damaged cells, longer-term surveillance is necessary; over many years, even a subtle alteration in the environmental milieu in this direction, although not inducing cancer, could result in acceleration of carcinogenesis. Finally, even if GH/IGF-1 therapy does result in a small increase in cancer risk compared to untreated patients with GH deficiency, it is likely that the eventual risk will be the same as the general population. Such a restoration to normality will need to be balanced against the known morbidity of untreated GH deficiency.
The above is a 2006 study on the use of GH and its association with cancer. So neither adults nor child cancer patients who were treated with GH (this is done to mitigate cachexia, cancer-induced muscle wasting and weakness) showed an increase in the incidence of cancer despite the theoretical link between IGF-1 (cell proliferator) and cancer risk (due to uncontrolled cell proliferation).
Dosing rHGH would only ever be dangerous in people who already have cancer - in that case, it MAY make your cancer spread faster, but it doesn't seem likely. Here's a meta-analysis from 2015 (almost 10 years after the previous one) analyzing ALL THE evidence since then on cancer and IGF-1:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5393518/Context:
GH and IGF-1 have been shown to affect tumor growth in vitro and in some animal models. This report summarizes the available evidence on whether GH therapy in childhood is associated with an increased risk of neoplasia during treatment or after treatment is completed.
Evidence Synthesis:
In children without prior cancer or known risk factors for developing cancer, the clinical evidence does not affirm an association between GH therapy during childhood and neoplasia. GH therapy has not been reported to increase the risk for neoplasia in this population, although most of these data are derived from postmarketing surveillance studies lacking rigorous controls. In patients who are at higher risk for developing cancer, current evidence is insufficient to conclude whether or not GH further increases cancer risk. GH treatment of pediatric cancer survivors does not appear to increase the risk of recurrence but may increase their risk for subsequent primary neoplasms.
Conclusions:
In children without known risk factors for malignancy, GH therapy can be safely administered without concerns about an increased risk for neoplasia. GH use in children with medical diagnoses predisposing them to the development of malignancies should be critically analyzed on an individual basis, and if chosen, appropriate surveillance for malignancies should be undertaken. GH can be used to treat GH-deficient childhood cancer survivors who are in remission with the understanding that GH therapy may increase their risk for second neoplasms.
So over 20 years after the "GH scare" started (due to mad cow disease caused by pituitary-derived HGH, which was extracted from the pituitary glands of human corpses; we don't use this anymore, we use synthetic - "recombinant", the "r" in rHGH - now), there's still ZERO conclusive evidence demonstrating a causal link between rHGH use and cancer incidence or even worsening.
2. "Acromegaly!!!!"Acromegaly patients have serum IGF-1 levels that are elevated several hundred times relative to the average person's. Also, the nature of their disease means that their basal HGH levels are elevated
24 hours a day, 7 days a week, 365 days a year for their entire lives starting from the onset of the disease.
You are not going to get """acromegaly""" from dosing 5-10 IU of cheap, sh*t-quality, underdosed, generic Chinese HGH you bought from some underground lab off the Dark Web. You would have to dose 10+ IU of rHGH every day, multiple times a day,
for a decade or more before you started noticing anything akin to "acromegaly". Don't believe me? Here is a study of an 11-year old who developed "acromegaly" as a result of rHGH replacement therapy:
http://journals.aace.com/doi/pdf/10.4158/EP14165.CR?code=aace-siteMethods: We report progressive features of acromegaly
as a consequence of inadvertent overreplacement of
GH, initiated for treatment of GH deficiency in an 11-yearold
male treated for craniopharyngioma.
Results: An 11-year-old male developed panhypopituitarism
after transsphenoidal resection of a craniopharyngioma.
Human GH (hGH) replacement therapy was subsequently
initiated for hypopituitarism, using a weight-based
dosing regimen, achieving adequate linear growth. After
9 years of hGH replacement therapy, prognathism and an
increase in shoe size were noted, with supporting radiographic
evidence of hGH overreplacement.
After 9 years of overdosing this child by who-knows-how-much, prognathism (jaw misalignment) and shoe size increase (note that they don't mention HOW MUCH) were noted.
9 years.Also, note that "acromegaly" is medically defined as
any unnatural growth of the extremities (skull, hands, feet, etc) that occurs after the growth phase of the individual has ended. That means that if your skull grows by a centimeter and a half, or if your shoe size goes up by .5, you technically have "acromegaly". This is what happened to the recently-deceased bodybuilder Rich Piana:
So after 12 years (!!!) of dosing over 10 I.U. of PHARMACEUTICAL GRADE (he is a rich bodybuilder and has the connections and money to afford it) rHGH a day, his shoe size went up from a size 12 to a size 15, his skull size went up - he mentions he used to wear a size 7 3/8, and after the GH, he now wears a size 7 3/4, and his hands and wrists have grown.
To that I say:
what's the problem? LMAO. If anything, CLL patients should be PRAYING this happens to them so that you aren't 5'10"+ with peanut skulls, 6 inch wrists and wearing size 9 Converse.
ALSO, regarding OP and the topic of this thread: Notice he does not say ANYTHING about height increase whatsoever, because he didn't get taller. Neither has any other bodybuilder who has used as much or more rHGH (Dorian Yates, Jay Cutler, basically ANY IFBB pro) Michael's hypothesis about rHGH overstimulation is just that, a hypothesis, one that is almost certainly FALSE. rHGH will NOT make you grow even a picometer after your epiphyseal cartilage has ossified.
With that out of the way, I repeat: you are not going to become Andre the Giant because you took "too much rHGH". You are
way, way WAYYYYY too poor to afford sufficient HIGH QUALITY rHGH to do this.
rHGH is an excellent tool for healing, anti-aging quality of life increase, etc. It isn't this big scary boogeyman the medical industry is trying to make it out to be. Stop buying into this bullsh*t. Educate yourself.
Seriously. It's comical how people on this board can be fully behind the idea of a barbaric, permanently athletically damaging surgery involved in several confirmed deaths and permanently crippled patients, but scared to death of IGF-1.
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Topic: small growth with HGH after growth plates "officially "fused (Read 5792 times)